Figure 4.
CBD inhibits BCRP-mediated transport. Concentration–time curves for prazosin in the presence of (a) vehicle, (b) elacridar, (c) CBD (d) CBDA, (e) CBDVA, (f) CBG or (g) Δ9-THC in the basolateral to apical (B > A) and apical to basolateral (A > B) directions in cells expressing BCRP. Elacridar and CBD significantly inhibit (red shading) transport of prazosin. Data are expressed as means ± SEM, with n = 3–4 per time point. Curves represent fits to a linear regression and transport efflux ratios (r) are listed (*p < 0.05, **p < 0.005, ***p < 0.0005 compared to vehicle; Extra sum-of-squares F test).