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Endomyocardial Biopsy Following Immunotherapy Rechallenge
(A) Hematoxylin and eosin stain of endomyocardial tissue demonstrating areas of myocardial necrosis (1), leading edge of inflammation with mononuclear invasion (2) of normal myocardium (3). (B) Higher power view of leading edge of mononuclear infiltration. (C to E) Immunohistochemical stains characterizing infiltrating cytotoxic T cells that stain positive for CD8, granzyme (arrows), and perforin (arrows), respectively.
