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CS-semi5 inhibits the development and progression of collagen-induced arthritis (CIA). (A) Schematic diagram of CIA model establishment. (B) Body weight growth rate was measured weekly. (C) The severity of arthritis swelling was evaluated by mean clinical scores weekly after second immunization. (D) Hind paw swelling was photographed on day 49. n = 7. # p < 0.05 and ## p < 0.01 compared with Control group; *p < 0.05 and **p < 0.01 compared with Model group.
