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. 2021 Jul 9;12:655101. doi: 10.3389/fphar.2021.655101

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Copyright © 2021 Li, Tang, Wang, Chai, Zhao, Zhang, Peng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CS-semi5 alleviates collagen-induced cartilage thickness reduction and cartilage loss in CIA mice. (A) Safranin O/fast green staining of ankle joints. Red arrows indicate cartilage. Original magnification was 100×, and 200× magnification was used in high-power views. Bar respectively indicates 100 and 50 μm. (B) The severity of cartilage loss was analyzed based on the OARSI score system. (C) Articular cartilage areas were quantified by tracing Safranin O-positive stained areas. n = 7. ^## p < 0.01 compared with Control group; *p < 0.05 and **p < 0.01 compared with Model group.