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Overview of CCM cell culture models. Features of hereditary and sporadic CCM disease (left subpanels) as well as the CRISPR/Cas9 genome editing approaches that have been used in this study (right subpanels) are schematically depicted (created with BioRender.com). Filled symbols in the pedigrees indicate CCM patients. CCM1 +/+ = cells with two CCM1 wild-type alleles; CCM1 +/− = cells with a heterozygous CCM1 mutation; CCM1 −/− = cells with biallelic CCM1 mutations.
