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. 2021 Jul 19;62(8):717–725. doi: 10.3349/ymj.2021.62.8.717

Table 4. Results of the Linear Mixed Effect Model for Regional Cortical Thickness and Hippocampal Volume.

Cortical region Group effect Time effect Group×time
β (95% CI) p value β (95% CI) p value β (95% CI) p value
Lt. cingulate thickness −0.06 (−0.17, 0.04) 0.233 −0.03 (−0.06, −0.002) 0.036 0.02 (−0.04, 0.07) 0.601
Rt. cingulate thickness 0.01 (−0.08, 0.10) 0.789 −0.05 (−0.07, −0.02) <0.001 0.01 (−0.03, 0.06) 0.544
Lt. frontal thickness −0.04 (−0.11, 0.02) 0.198 −0.04 (−0.06, −0.02) <0.001 0.001 (−0.04, 0.04) 0.943
Rt. frontal thickness −0.02 (−0.08, 0.04) 0.491 −0.04 (−0.06, −0.02) <0.001 0.01 (−0.02, 0.05) 0.399
Lt. parietal thickness −0.04 (−0.14, 0.05) 0.376 −0.06 (−0.08, −0.03) <0.001 0.01 (−0.04, 0.06) 0.581
Rt. parietal thickness −0.01 (−0.10, 0.08) 0.859 −0.05 (−0.06, −0.03) <0.001 −0.005 (−0.04, 0.03) 0.782
Lt. temporal thickness −0.05 (−0.14, 0.04) 0.260 −0.07 (−0.09, −0.04) <0.001 −0.000008 (−0.05, 0.05) 0.999
Rt. temporal thickness −0.03 (−0.12, 0.06) 0.532 −0.06 (−0.08, −0.04) <0.001 0.01 (−0.04, 0.05) 0.664
Lt. occipital thickness −0.003 (−0.11, 0.10) 0.954 −0.07 (−0.10, −0.04) <0.001 0.02 (−0.04, 0.08) 0.546
Rt. occipital thickness 0.01 (−0.08, 0.11) 0.778 −0.05 (−0.07, −0.03) <0.001 0.02 (−0.02, 0.07) 0.309
Lt. hippocampal volume 42.72 (−275.9, 361.4) 0.788 −116.39 (−200.6, −32.2) 0.008 43.30 (−126.0, 212.6) 0.609
Rt. hippocampal volume −12.77 (−344.7, 319.2) 0.939 −111.22 (−201.3, −21.1) 0.017 61.50 (−119.1, 242.1) 0.496

β, beta coefficient; CI, confidence interval; Lt, left; Rt, right.

The terms for time were defined as 0 for baseline and 1 for 12-month follow-up.