Table 4.
Results of the meta-analysis.
| Results | N | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | AUC (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| NEWS2 | 14 | 0.82 (0.75, 0.87) | 0.67 (0.58, 0.75) | 2.50 (1.96, 3.20) | 0.27 (0.20, 0.37) | 0.82 (0.79, 0.85) | ||
| NEWS | 7 | 0.75 (0.63, 0.84) | 0.65 (0.52, 0.76) | 2.13 (1.58, 2.87) | 0.39 (0.27, 0.56) | 0.76 (0.72, 0.79) | ||
| qSOFA | 6 | 0.26 (0.20, 0.33) | 0.94 (0.86, 0.97) | 4.13 (1.88, 9.08) | 0.79 (0.73, 0.86) | 0.64 (0.78, 0.84) | ||
| SUBGROUP ANALYSIS | ||||||||
| Time of outcome measurement | ||||||||
| Within 72 h | 5 | 0.88 (0.74, 0.95) | 0.56 (0.36, 0.74) | 2.01 (1.39, 2.91) | 0.21 (0.12, 0.37) | 0.82 (0.79, 0.85) | ||
| In-hospital | 12 | 0.79 (0.74, 0.84) | 0.70 (0.61, 0.77) | 2.62 (2.01, 3.42) | 0.30 (0.23, 0.39) | 0.82 (0.79, 0.85) | ||
| Disease severity | ||||||||
| Light (mortality rate <10%) | 4 | 0.79 (0.67, 0.87) | 0.76 (0.62, 0.86) | 3.27 (2.01, 5.32) | 0.28 (0.18, 0.45) | 0.83 (0.79, 0.86) | ||
| Severe (mortality rate ≥10%) | 9 | 0.82 (0.72, 0.89) | 0.63 (0.51, 0.47) | 2.22 (1.69, 2.92) | 0.29 (0.19, 0.43) | 0.80 (0.76, 0.83) | ||
| Sensitivity analysis | ||||||||
| NEWS2 ≥ 5 | 12 | 0.82 (0.74, 0.88) | 0.66 (0.55, 0.76) | 2.44 (1.84, 3.22) | 0.27 (0.19, 0.38) | 0.82 (0.79, 0.85) | ||
| Calculating score at admission | 12 | 0.78 (0.72, 0.83) | 0.70 (0.61, 0.77) | 2.56 (1.98, 3.32) | 0.32 (0.25, 0.41) | 0.81 (0.77, 0.84) | ||
NEWS, National Early Warning Score; NEWS2, National Early Warning Score 2; qSOFA, quick Sequential Organ Failure Assessment; N, number of studies; CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; AUC, area under the curve.