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. 2021 Jul 14;22(3):666. doi: 10.3892/ol.2021.12927

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Niclosamide combined with cisplatin reverses cisplatin resistance. (A) Typical images of BT-CS and BT-CR cells. Images were obtained using a microscope (Zeiss) with a 40X objective lens. (B) Alamar Blue assay was used to assess the cell viability. BT-CS and BT-CR cells were treated with the indicated concentrations of cisplatin for 48 h. (C) BT-CR cells were treated with the indicated concentrations of cisplatin and niclosamide or the combination of these two drugs for 48 h. (D) CI plot obtained from the CompuSyn report for BT-CR cells treated with cisplatin and niclosamide combinations. ***P<0.001. BT-CS, cisplatin sensitive BT474 cells; BT-CR, cisplatin resistant BT474 cells; Ctrl, control; CI, combination index.