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. 2021 Jul 14;22(3):666. doi: 10.3892/ol.2021.12927

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Niclosamide and cisplatin induce apoptosis in resistant cells. (A) Cisplatin resistant BT474 cells were cultured with DMSO (control), cisplatin (20 µM), niclosamide (1 µM) or niclosamide (1 µM) combined with cisplatin (20 µM) for 48 h and then subjected to apoptosis analysis. Lower and upper right quadrants of the scatterplots show the percentages of early and late apoptotic cells, respectively. (B) Percentage of early and late apoptotic cells detected by flow cytometry. n=3. ***P<0.001. Ctrl, control; Cis, cisplatin; Ncm, niclosamide.