TABLE 5.
Studies reporting altered levels of caspase-9 in autoimmune disease.
| Disease (n) | Controls (n) | Casp9 Measured | Detection Method | Tissue examined | Pathological Casp9 Localization | Ref. |
|---|---|---|---|---|---|---|
| Sepsis (107) | Normal (89) | Total casp9 | ELISA | Serum | -- | Miliaraki et al. (2021) |
| SIRS (75) | ||||||
| Immunodeficiency/lymphoproliferation (2) | -- | Caspase activity | LEHD cleavage | Blood | PBMC | Clemente et al. (2015) |
| Casp9 H237P | Genotyping | |||||
| Behçet’s disease (15) | Normal (9) | Total casp9 | IHC | Aphthous lesion (biopsy) | Endothelial cells | Oztas et al. (2007) |
| Behcet’s disease (7) | Normal (7) | Caspase activity | LEHD cleavage | Blood | Neutrophils | Nazıroğlu et al. (2014) |
SIRS, Traumatic Systemic Inflammatory Syndrome; PBMCs, Peripheral blood mononuclear cells.