Figure 1.

Levels of mRNA coding for synaptic protein VAMP1 in 3-month-old mouse cortex–effect of AβPP expression and FTY720 administration. Levels of mRNAs measured with real-time PCR in the cerebral cortex of 3-month-old (adult) mice as described in Materials and methods. Results from AβPP-expressing mice were compared with those from control animals that did not inherit the transgene. Effect of FTY720 administration was assessed against vehicle-treated animals of the same group. Vamp1, vesicle-associated membrane protein 1; APP⁻, animals without V717I AβPP transgene; APP⁺, mice expressing V717I AβPP transgene. ^***p < 0.001 vs. corresponding controls, two-way ANOVA followed by Tukey's post-hoc test (significances marked over the horizontal bar describe the difference between vehicle-treated control animals and vehicle-treated AβPP-expressing mice). n = 6–7, measured in tri- to quadruplicate ± SEM.