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. 2021 Jul 9;14:660104. doi: 10.3389/fnmol.2021.660104

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Copyright © 2021 Jęśko, Wieczorek, Wencel, Gąssowska-Dobrowolska, Lukiw and Strosznajder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of changes in genes coding synaptic proteins and their possible consequences observed in 12-month (12 M) FVB/AβPP (V717I) mice cortex and hippocampus. The effect of fingolimod (FTY720, marked by green dashed square) on genes that expression was altered in AD mice brain was bolded and marked with circles (ellipses). Snap25, synaptosomal-associated protein, 25kDa; Stx1a, syntaxin 1A; Vamp1, vesicle-associated membrane protein 1; Nrxn1, neurexin 1; Cplx1, complexin 1; Syt1, synaptotagmin 1; Syp, synaptophysin; Nefl, neurofilament light.