Fig. 5.

Lysosomal Ca²⁺dynamics and viral entry. A variety of viruses target lysosomal Ca²⁺ efflux channels for host cell entry via endocytic route. Viruses such as EBOV, Marburg virus, Polyoma virus and MERS-CoV target TPCs for facilitating receptor mediated entry into host cells. Importantly, TPCs also regulate SARS-CoV-2 entry into host cells. While TRPML1 regulates HIV-1 replication and latent infection.