Figure 5.

Cellular targets of SARS-CoV-2 in the nasopharynx

(A) Summary schematic of top SARS-CoV-2 RNA⁺ cells. (Adapted from “Coronavirus Replication Cycle (Simplified) by BioRender.com (2021). Retrieved from https://app.biorender.com/biorender-templates.)

(B) SARS-CoV-2 RNA⁺ cell number (top) and percent (bottom) per participant.

(C) Abundance of SARS-CoV-2 RNA⁺ cells by detailed cell type, bars colored by participant.

(D) Dot plot of SARS-CoV-2 RNA presence by sample (columns) and detailed cell types (rows). Dot size reflects fraction of a given participant and cell type containing SARS-CoV-2 RNA. Dot color reflects fraction of aligned reads corresponding to the SARS-CoV-2-positive strand (yellow) versus negative strand (black). Top dot plot across columns: alignment of viral reads by participant, separated by RNA species type. Right dot plot across rows: alignment of viral reads by detailed cell type.

(E) Percent ACE2⁺ cells versus percent SARS-CoV-2 RNA⁺ cells by coarse cell type (left) and detailed cell type (right).

See also Figures S5 and S6.