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. 2021 Jul 23;184(19):4969–4980.e15. doi: 10.1016/j.cell.2021.07.025

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Figure S6 — Representative flow plots for mAb binding and neutralization of indicated variants, related to Figure 6

Flow plots for binding of 7 mAbs to Nextstrain cluster 20A.EU1 (A222V), Danish mink variant (Δ69-70 and Y453F), B.1.1.7 (Δ69-70, Δ144, N501Y, A570D, P681H, T716I, S982A, D1118H), B.1.351 (L18F, D80A, D215G, Δ241-243, K417N, E484K, N501Y, A701V), P.1 (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, D1176F) and NTD deletion variants. All variants contain the D614G mutation. Plasmids with variant S co-expressed with pmaxGFP in HEK293T cells. Cells were gated on DAPi⁻GFP⁺. mAb C81E2 was used as positive control, and PBS, as negative control. (B) Authentic B.1.1.7 virus neutralization profiles for 6 antibodies. (C) Authentic B.1.351 virus neutralization profiles for 6 antibodies. Data are mean values ± SD for authentic virus assays.