Table 2b.
Multiple logistic regression analysis for a negative humoral immune response to SARS-CoV-2 vaccination compared to a positive immune response in unexposed kidney transplant recipients of the DIA-Vacc pure vaccination cohort between T0 and T2.
| Risk factor | OR | Wald CI | p-value | |
|---|---|---|---|---|
| Sex | Male | Ref. | ||
| Female | 0.866 | [0.526; 1.425] | 0.571 | |
| Age | per year | 1.027 | [1.008; 1.047] | 0.006 |
| BMI | Per unit | 0.989 | [0.942; 1.039] | 0.669 |
| Time on transplantation | per year | 0.946 | [0.911; 0.982] | 0.004 |
| Number of comorbidities | per one | 0.952 | [0.653; 1.387] | 0.797 |
| Hepatitis B vaccination failure | No | Ref. | ||
| Yes | 0.449 | [0.189; 1.065] | 0.069 | |
| Number of IS drugs | Per one | 2.055 | [1.338; 3.157] | 0.001 |
| Vaccine type | BNT162b2 mRNA | Ref. | ||
| mRNA-1273 | 0.356 | [0.205; 0.616] | < 0.001 | |
Ref. = reference category; IS means immunosuppression; T0 = before first vaccination; T2 = 8 weeks after first vaccination.
Comparator is the kidney transplant recipient cohort, which shows a positive immune reaction to vaccination as defined by de novo development of any IgG-Ab or IgA-Ab against the Spike S1 subunit on T2. A negative vaccination response was defined by negative results of both above tests at T2.