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. 2021 Jul 23;9:100178. doi: 10.1016/j.lanepe.2021.100178

Table 2d.

Success/positive rates of humoral vaccination-related de novo immune response dependent on immunosuppression number, type or vaccine type at T2.

Factors category DP KTR MP
Total Numbers n 1136 368 144
Immunosuppressive drugs n /% 63 / 6 367 / 99•8 1 / 0•7
No IS drug % of group number 96% of 1048 100% of 1 n.a.
One IS drug % of group number 78% of 37 84% of 19 n.a.
Two IS drugs % of group number 62% of 13 43% of 180 n.a.
Three IS drugs % of group number n.a. 35% of 128 n.a.
CS % of group number 82% of 28 n.a. n.a.
CS/CNI % of group number n.a. 56% of 25 n.a.
CNI/MMF-MPA % of group number n.a. 39% of 123 n.a.
CNI/mTOR-I % of group number n.a. 38% of 13 n.a.
CS/CNI/MMF-MPA % of group number n.a. 34% of 102 n.a.
CS/CNI/mTOR-I % of group number n.a. 50% of 12 n.a.
Belatacept alone or in a combination % of group number n.a. 19% of 16 n.a.
Vaccine Type % of group number 95% of 1136 42% of 333 99% of 134
BNT162b2 mRNA % of group number 88% of 200* 26% of 99* 97% of 39
mRNA-1273 % of group number 97% of 936 49% of 234 99% of 95

MP = Medical Personnel; DP = Dialysis Patients; KTR = Kidney Transplant Recipient; IS means immunosuppression. CNI = Calcineurin-Inhibitor; MMF-MPA = mycophenolate mofetil or mycophenolic acid; mTOR-I = mTOR-inhibitors; CS = glucocorticosteroids; T2 = 8 weeks after first vaccination.

Vaccination response rates in drug combinations of less than 10 patients were reported as n.a.;.

statistical significance using p < 0•001 compared to other vaccine type;.