Table 2d.
Success/positive rates of humoral vaccination-related de novo immune response dependent on immunosuppression number, type or vaccine type at T2.
Factors | category | DP | KTR | MP |
---|---|---|---|---|
Total Numbers | n | 1136 | 368 | 144 |
Immunosuppressive drugs | n /% | 63 / 6 | 367 / 99•8 | 1 / 0•7 |
No IS drug | % of group number | 96% of 1048 | 100% of 1 | n.a. |
One IS drug | % of group number | 78% of 37 | 84% of 19 | n.a. |
Two IS drugs | % of group number | 62% of 13 | 43% of 180 | n.a. |
Three IS drugs | % of group number | n.a. | 35% of 128 | n.a. |
CS | % of group number | 82% of 28 | n.a. | n.a. |
CS/CNI | % of group number | n.a. | 56% of 25 | n.a. |
CNI/MMF-MPA | % of group number | n.a. | 39% of 123 | n.a. |
CNI/mTOR-I | % of group number | n.a. | 38% of 13 | n.a. |
CS/CNI/MMF-MPA | % of group number | n.a. | 34% of 102 | n.a. |
CS/CNI/mTOR-I | % of group number | n.a. | 50% of 12 | n.a. |
Belatacept alone or in a combination | % of group number | n.a. | 19% of 16 | n.a. |
Vaccine Type | % of group number | 95% of 1136 | 42% of 333 | 99% of 134 |
BNT162b2 mRNA | % of group number | 88% of 200* | 26% of 99* | 97% of 39 |
mRNA-1273 | % of group number | 97% of 936 | 49% of 234 | 99% of 95 |
MP = Medical Personnel; DP = Dialysis Patients; KTR = Kidney Transplant Recipient; IS means immunosuppression. CNI = Calcineurin-Inhibitor; MMF-MPA = mycophenolate mofetil or mycophenolic acid; mTOR-I = mTOR-inhibitors; CS = glucocorticosteroids; T2 = 8 weeks after first vaccination.
Vaccination response rates in drug combinations of less than 10 patients were reported as n.a.;.
statistical significance using p < 0•001 compared to other vaccine type;.