Table 1.

Top 20 significant drug candidates identified for shared DEGs between SARS-CoV-2 and T2D.

Drug/small molecule	$p$-value	Adj. $p$-value	Associated genes
Phencyclidine	1.16E-15	4.68E-12	IL1A, CCL20, IL1B, TNFAIP2, LIF, CXCL1, CXCL3, PTGS2, ICAM1, TYMP, BIRC3
Profenamine	1.94E-14	3.91E-11	IL1B, LIF, CXCL1, INHBA, CXCL3, PTGS2, ICAM1, BIRC3
8-Azaguanine	5.99E-14	8.04E-11	IL1A, CCL20, IL1B, LIF, CXCL1, INHBA, CXCL3, PTGS2, KRT6B, ICAM1, BIRC3
Nickel chloride	6.02E-13	6.06E-10	IL1A, CCL20, IL1B, TNFAIP2, CXCL1, INHBA, LTB, CXCL3, PTGS2, ICAM1, BIRC3
Chloropyramine	2.62E-12	2.11E-09	LIF, CXCL1, INHBA, PTGS2, ICAM1, BIRC3
Pizotifen	2.36E-11	1.58E-08	CXCL1, INHBA, CXCL3, PTGS2, ICAM1, BIRC3
MS-275	4.76E-11	2.74E-08	C3, IL1A, CCL20, IL1B, TNFAIP2, CXCL1, PTGS2, KRT6B, S100A8, BIRC3
0297417-0002B	1.53E-10	7.74E-08	LIF, CXCL1, LTB, PTGS2, KRT6B, ICAM1, BIRC3
Silica	1.89E-10	8.45E-08	ANLN, IL1A, EGR3, CCL20, IL1B, TNFAIP2, CXCL1, LTB, CXCL3, PTGS2, ICAM1, BIRC3
Gemcitabine	2.93E-10	1.07E-07	IL1A, CCL20, IL1B, CXCL1, CXCL3, ICAM1, TYMP, BIRC3
Peptidoglycan	3.313E-10	1.11E-07	IL1A, CCL20, IL1B, PTGS2, ICAM1
1-Nitropyrene	2.83E-10	1.14E-07	IL1A, CCL20, IL1B, CXCL1, LTB, CXCL3, ICAM1, BIRC3
Estradiol	8.55E-10	2.45E-07	EGR3, MME, CCL20, SLC6A14, ADAM22, LIF, KRT23, INHBA, CXCL3, PTGS2, ICAM1, C3, ANLN, IL1A, VNN1, IL1B, LTB, KRT6B, S100A8, BIRC3
Nickel sulphate	8.04E-10	2.49E-07	IL1A, CCL20, IL1B, CXCL1, INHBA, CXCL3, PTGS2, ICAM1, TYMP, BIRC3
3-Nitrofluoranthene	9.33E-10	2.50E-07	CCL20, CXCL1, LTB, CXCL3
Dexamethasone	1.12E-09	2.67E-07	IL1B, SLC6A14, LIF, LTB, PTGS2, S100A8, ICAM1, TYMP, BIRC3
Niclosamide	1.10E-09	2.77E-07	CCL20, CXCL1, INHBA, CXCL3, PTGS2, ICAM1, BIRC3
MG-132	1.35E-09	3.02E-07	IL1A, IL1B, CXCL1, PTGS2, ICAM1, TYMP, BIRC3
Simvastatin	2.24E-09	4.75E-07	IL1A, IL1B, LIF, LTB, PTGS2, S100A8, ICAM1, BIRC3
Thioridazine	3.22E-09	6.49E-07	LIF, INHBA, LTB, CXCL3, PTGS2, ICAM1, BIRC3