Figure 6. Schematic diagram demonstrating the novel signaling pathway involving EGFR–TRPM7 interaction in VSMCs.

EGFR activation by EGF results in c-Src activation, which is required for TRPM7 activity (phosphorylation and expression) contributing to Mg²⁺ homeostasis and interaction of EGFR and TRPM7 in the cell membrane. This signaling pathway is required for activation of ERK1/2. Cross-talk between EGF–EGFR and TRPM7 in VSMCs regulates cell migration and proliferation and may play an important role in vascular homeostasis.