Table V.
Steatosis-Activity-Fibrosis (SAF) scoring system of NAFLD (from Bedossa et al., 2012) 34.
| Steatosis grade (S): 0-3 | Hepatocyte ballooning: 0-2 |
| Based on percentage of hepatocytes with large and/or medium size intracytoplasmic lipid droplets S0: < 5% S1: 5-33% S2: 34-66% S3: > 66% |
0: none 1: Cluster of rounded hepatocytes with pale/reticulated cytoplasm 2: Same as 1 with enlarged hepatocytes (more than twice of normal size) |
| Lobular inflammation: 0-2 | Activity grade (A): 0-4 |
| 0: None 1: ≤ 2 foci/20x field 2: > 2 foci/20x field |
Sum of score for ballooning and lobular inflammation A1 (A = 1): Mild activity A2 (A = 2): Moderate activity A3 and A4 (A > 2): Severe activity |
| Fibrosis stage (F) | SAF score |
| F0: no significant fibrosis F1: 1a Mild zone 3 sinusoidal fibrosis 1b Moderate zone 3 sinusoidal fibrosis 1c Portal fibrosis only F2: zone 3 sinusoidal fibrosis with periportal fibrosis F3: Bridging fibrosis F4: Cirrhosis |
S0-3; A0-4; F0-4 |