Table 4.

Differential diagnosis of Kleine-Levin syndrome.

	Clue for Diagnosis
Complex partial seizures	EEG
Lyme disease	Serology, brain MRI
Narcolepsy	Polysomnography
Herpes simplex virus encephalitis	CSF PCR test
Intermittent porphyria	Laboratory test
Klüver-Bucy syndrome (bilateral temporal lobe lesions)	Brain MRI
Metabolic encephalopathies	Laboratory test
Menstruation-related hypersomnia	History of symptoms temporal pattern
Sleep disordered breathing	History of OSA
Primary psychiatric illness (depression, bipolar disorder)	Hystory of psychiatric illness
Medication or substance abuse	History of drugs abuse