FIGURE 1.

Data landscape of BXD mice strains and lifespan. (A) The selection of datasets for the in silico analysis. All of the sets listed are downloaded from gene network 2 or GEO databases (http://gn2.genenetwork.org/ either directly or by the reference GEO accession). The strain’s total amount refers to the subset of the study strains which could be mapped to median strain lifespan values. See Supplementary Tables 1, 2 for details. (B–I) Ordered strain median lifespans for each tissue. Adrenal gland male (B) female (C), kidney male (D), female (E), liver female for transcriptomics (F), liver female for proteomics (G), bone femur male (H), and sex-combined eye tissue (I). The analyses encompass the subset of BXD strains which, within each dataset, were mappable to the employed experiment for BXD lifespans. In black are the top four shortest and longest-lived BXD mice strains.