Table 4.
Associations of Changes in Cardiac Mechanics after Passive Leg Raise with 6MWD.
| Echocardiographic Variable (independent variable) | β coefficient (meters) per SD decrease (95% CI) | P value |
|---|---|---|
| LA Function | ||
| ΔLA reservoir strain | ||
| Model 1* | −9.9 (−13.5, −6.4) | <0.001 |
| Model 2† | −5.8 (−9.1, −2.5) | <0.001 |
| ΔLA booster strain | ||
| Model 1* | −3.4 (−7.3, 0.4) | 0.08 |
| Model 2† | −2.4 (−6.0, 1.2) | 0.19 |
| LV Diastolic Function | ||
| ΔLateral e’ velocity | ||
| Model 1* | −4.7 (−8.4, −0.9) | 0.02 |
| Model 2† | −2.7 (−6.2, 0.8) | 0.13 |
| ΔE/e’ average | ||
| Model 1* | 6.7 (2.7, 10.8) | 0.001 |
| Model 2† | 3.4 (−0.4, 7.2) | 0.08 |
| Hemodynamics | ||
| ΔSV | ||
| Model 1* | 6.1 (−1.6, 13.8) | 0.12 |
| Model 2† | −3.2 (−10.4, 4.0) | 0.38 |
*
Adjusted for age, race/ethnicity, sex, study site, education status, and respective resting measure of cardiac mechanics.
†
Adjusted for Model 1 variables plus smoking status, systolic blood pressure, heart rate, body mass index, diabetes, estimated glomerular filtration rate, anti-hypertensive medication, NT-proBNP, atrial fibrillation, coronary heart disease, stroke, LV mass, and LA volume.
LA = left atrial; LV = left ventricular; SV = stroke volume