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. 2021 Feb 1;32(7):1374–1392. doi: 10.1021/acs.bioconjchem.0c00691

Scheme 2. Coupling Reaction Scheme of Functionalized Porphyrin-Based Conjugates with Peptides.

Scheme 2

Reagents and conditions: (i) succinic anhydride, TEA, CHCl3; (ii) PyBOP, DIPEA, DMF, BBN[7-13]; (iii) 3-maleimidopropionic acid, HOBt, EDC·HCl, DCM; (iv) Cys-BBN[7-14]-NH2, pyridine, DMSO; (v) dibenzocyclooctyne acid, HOBt, EDC·HCl, DIPEA, DCM; (vi) 11-azido undecanoyl-BBN[7-14]-NH2, DMSO.