Table 2.
CircRNAs that play oncogenic roles in breast cancer.
| CircRNA name | Circbase ID | Length | Gene Name | Distribution | Phenotype | Target | Downstream genes/ pathways |
Reference |
|---|---|---|---|---|---|---|---|---|
| circSEPT9 | hsa_circ_ 0005320 | 645 | SEPT6 | cytoplasm | promote cell proliferation and migration in vitro | miR-637 | LIF/STAT3 | (32) |
| circular RNA CDR1as | hsa_circ_0001946 | 1485 | CDR1 | \ | increase chemosensitivity of 5-FU-resistant BC cells | miR-7 | CCNE1 | (69) |
| hsa_circ_0006528 | hsa_circ_0006528 | 496 | PRELID2 | \ | promote adriamycin resistance | miR-7-5p | Raf1 | (70) |
| hsa_circRNA_0006528 | hsa_circ_0006528 | 496 | PRELID2 | \ | promote cell proliferation, invasion, and migration, inhibit apoptosis | miR-7-5p | Raf1-MAPK/ERK | (71) |
| hsa_circRNA_0000518 | hsa_circ_0000518 | 150 | RPPH1 | \ | and promote cell proliferation, migration, invasion, inhibit cell cycle arrest, apoptosis, in vitro, and promote tumor growth in vivo | miR-326 | FGFR1 | (72) |
| circIQCH | hsa_circ_0104345 | 864 | IQCH | cytoplasm | promote cell proliferation, migration in vitro, and promote tumor growth, and metastasis in vivo | miR-145 | DNMT3A | (73) |
| circZNF609 | hsa_circ_0000615 | 874 | ZNF609 | cytoplasm | promote cell proliferation, invasion and migration in vitro, and promote tumor growth in vivo | miR-145-5p | p70S6K1 | (74) |
| hsa_circ_0136666 | hsa_circ_0136666 | 477 | PRKDC | \ | promote cell proliferation | miR-1299 | CDK6 | (75) |
| circ_0006528 | hsa_circ_0006528 | 496 | PRELID2 | \ | promote proliferation, migration, invasion, autophagy, and inhibit cell apoptosis of PTX-resistant breast cancer cells | miR-1299 | CDK8 | (76) |
| circ_0001667 | hsa_circ_0001667 | 456 | HEATR2 | \ | promote cell proliferation, invasion, and migration in vitro | miR-125a-5p | TAZ | (77) |
| hsa_circ_0052112 | hsa_circ_0052112 | 209 | ZNF83 | cytoplasm | promote cell migration and invasion in vitro | miR-125a-5p | ZNF83 | (78) |
| circHMCU | hsa_circ_0000247 | 792 | MCU | cytoplasm | promote cell proliferation, migration, and invasion in vitro, and promote tumor growth and lung metastasis in vivo | let-7 | MCY, HMGA2, and CCND1 | (79) |
| circ-ABCB10 | \ | \ | ABCB10 | \ | decrease PTX sensitivity and apoptosis, promote cell invasion and autophagy of PTX-resistant BC cells | let-7a-5p | DUSP7 | (80) |
| circPLK1 | hsa_circ_0038632 | 1708 | PLK1 | cytoplasm | promote cell proliferation, invasion in vitro, and tumor occurrence and metastasis in vivo | miR-296-5p | PLK1 | (81) |
| hsa_circ_0000515 | hsa_circ_0000515 | 229 | RPPH1 | cytoplasm | promote cell proliferation, invasion, angiogenesis, and enhance inflammatory response in vitro, promote tumor growth in vivo | miR-296-5p | CXCL10 | (82) |
| hsa_circ_0011946 | hsa_circ_0011946 | 782 | SCMH1 | \ | promote cell migration and invasion | miR-26a/b | RFC3 | (51) |
| circWWC3 | hsa_circ_0089866 and hsa_circ_0001910 | 1068 and 825 | WWC3 | cytoplasm | promote cell proliferation, migration, and invasion | miR-26b-3p and miR-660-3p | ZEB1 | (83) |
| circ-DNMT1 | hsa_circ_0049224 | 155 | DNMT1 | cytoplasm | promote cell proliferation | \ | interact with p53 and AUF1 |
(84) |
| FECR1 | \ | 571 | FLI1 | both cytoplasm and nucleus | promote cell invasion in vitro | \ | binds to the FLI1 promoter in cis and recruits TET1, binds to and downregulates DNMT1 in trans | (85) |
| circular HER2 | hsa_circ_0007766 | 676 | ERBB2 | cytoplasm | promote cell proliferation, invasion, and tumorigenesis in vitro and in vivo | encoded a novel protein, HER2-103 | promote homo/hetero dimerization of EGFR/HER3, sustain AKT phosphorylation | (86) |
| circIFI30 | hsa_circ_0005571 | 351 | IFI30 | cytoplasm | promote cell proliferation, migration, invasion, inhibit apoptosis in vitro, and promote tumorigenesis and metastasis in vivo | miR-520b-3p | CD44 | (87) |
| circAGFG1 | hsa_circ_0058514 | 527 | AGFG1 | cytoplasm | promote cell proliferation, mobility, and invasion in vitro, promote tumorigenesis and metastasis in vivo | miR-195-5p | CCNE1 | (54) |
| circKIF4A | hsa_circ_0007255 | 355 | KIF4A | cytoplasm | promote cell proliferation, migration in vitro, and promote tumor growth and metastasis in vivo | miR-375 | KIF4A | (88) |
| circEPSTI1 | hsa_circ_0000479 | 375 | EPSTI1 | cytoplasm | promote cell proliferation and inhibit apoptosis | miR-4753 and miR-6809 | BCL11A | (56) |
| circGNB1 | hsa_circ_0009362 | 152 | GNB1 | cytoplasm | promote cell proliferation, migration in vitro, and tumor growth in vivo | miR-141-5p | IGF1R | (89) |
| circ-ABCB10 | hsa_circ_0008717 | 724 | ABCB10 | \ | promote cell proliferation and inhibit apoptosis in vitro | miR-1271 | \ | (57) |
| hsa_circ_0001982 | hsa_circ_0001982 | 899 | RNF111 | \ | promote cell proliferation, invasion, and inhibit apoptosis | miR-143 | \ | (59) |
| circANKS1B | hsa_circ_0007294 | 459 | ANKS1B | cytoplasm | promote cell invasion and migration in vitro, promote metastasis in vivo | miR-148a-3p and miR-152-3p | USF1-TGF-β1/SMAD | (61) |
| hsa_circ_0004771 | hsa_circ_0004771 | 203 | NRIP1 | \ | promote tumor growth and inhibit apoptosis | miR-653 | ZEB2 | (62) |
| circGFRA1 | hsa_circ_0005239 | 427 | GFRA1 | cytoplasm | promote cell proliferation and inhibit apoptosis in vitro | miR-34a | GFRA1 | (90) |
| circRNA_069718 | hsa_circ_0069718 | 590 | DCUN1D4 | \ | promote cell proliferation, invasion in vitro | \ | reduce the expression of Wnt/β-catenin pathway-related genes | (91) |
| circular RNA ciRS-7 | hsa_circ_0001946 | 1485 | antisense strand of CDR1 | cytoplasm | promote cell migration and invasion in vitro | miR-1299 | MMPs | (92) |
| circRNA-CER | hsa_circ_0023404 | 180 | RNF121 | \ | promote cell proliferation and migration in vitro | miR−136 | MMP13 | (93) |
| circ-RNF111 | hsa_circ_0001982 | 899 | RNF111 | \ | promote cell proliferation, invasion, glycolysis, and PTX resistance in PTX-resistant BC cells in vitro, and enhanced PTX sensitivity in vivo | miR-140-5p | E2F3 | (94) |
| circACAP2 | \ | \ | \ | cytoplasm | promote cell proliferation and motility | miR-29a/b-3p | COL5A1 | (95) |
| circVAPA | hsa_circ_0006990 | 338 | VAPA | cytoplasm | promote cell proliferation, migration, invasion | miR-130a-5p | \ | (96) |
| hsa_circ_002178 | \ | \ | \ | cytoplasm | promote cell proliferation, invasion, and migration | miR-1258 | KDM7A | (97) |
| hsa-circ-0083373, hsa-circ-0083374, hsa-circ-0083375 | hsa_circ_0083373, hsa_circ_0083374, hsa_circ_0083375 | 3868,4045,5469 | DLC1 | \ | promote pathogenesis and development of breast cancer | hsa-miR-511 | \ | (98) |
| circRNA_100876 | \ | \ | \ | \ | promote cell proliferation and invasion | miR-4753 and miR-6809 | BCL11A | (99) |
| circ_0103552 | hsa_circ_0103552 | 920 | UBR1 | \ | promote cell proliferation, migration, invasion, and inhibit apoptosis | miR-1236 | \ | (100) |
| circMMP11 | hsa_circ_0062558 | 906 | MMP11 | cytoplasm | promote cell proliferation and migration in vitro | miR-1204 | MMP11 | (101) |
| circ-UBE2D2 | \ | \ | UBE2D2 | \ | promote cell proliferation, migration, and invasion in vitro | miR-1236 and miR-1287 | \ | (102) |
| circ_UBE2D2 | hsa_circ_0005728 | 280 | UBE2D2 | cytoplasm | promote tamoxifen resistance | miR-200a-3p | \ | (103) |
| circUBE2D2 | hsa_circ_0005728 | 280 | UBE2D2 | cytoplasm | promote cell proliferation, migration, and invasion, and doxorubicin resistance in vitro, promote tumor growth in vivo | miR-512-3p | CDCA3 | (104) |
| hsa_circ_0091074 | hsa_circ_0091074 | 373 | TCONS_00016926 | \ | promote cell proliferation and invasion | miR−1297 | TAZ/TEAD4 | (105) |
| circ_0000043 | hsa_circ_0000043 | 438 | PUM1 | \ | promote cell proliferation, migration, invasion, and EMT | miR-136 | SMAD3 | (106) |
| hsa_circ_0003645 | hsa_circ_0003645 | 356 | C16orf62 | cytoplasm | promote cell proliferation and inhibit cell apoptosis in vitro and in vivo | miR-139-3p | HMGB1 | (107) |
| circCDYL | hsa_circ_0008285 | 667 | CDYL | cytoplasm | promote the malignant progression in vitro and in vivo | miR-1275 | ATG7 and ULK1 | (108) |
| circ_0000520 | hsa_circ_0000520 | 123 | RPPH1 | cytoplasm | promote cell proliferation, migration, and invasion, but inhibit cell cycle arrest and apoptosis | miR-1296 | SP1 | (109) |
| circular RNA KIF4A | hsa_circ_0007255 | 355 | KIF4A | cytoplasm | promote cell migration, invasion, and inhibit apoptosis | miR-152 | ZEB | (110) |
| circABCC4 | hsa_circ_0030586 | 1192 | ABCC4 | \ | promote cell proliferation, migration, invasion, and inhibit apoptosis | miR-154-5p | promote NF-κB and WNT/β-catenin pathways | (111) |
| circDENND4C | \ | \ | DENND4C | \ | increase glycolysis, migration, and invasion under hypoxia | miR-200b and miR-200c | MMP2, MMP9 | (112) |
| circDENND4C | \ | \ | \ | \ | promote cell migration and invasion under hypoxia in vitro, promote tumor growth in vivo | \ | \ | (113) |
| circHIPK3 | hsa_circ_0000284 | 1099 | HIPK3 | cytoplasm | promote cell proliferation, migration, and invasion in vitro and tumor growth in vivo | miR-193a | HMGB1/PI3K/AKT | (114) |
| hsa_circ_001783 | \ | 34460 | EBLN3- ZCCHC7 | cytoplasm | promote cell proliferation and invasion | miR-200c-3p | \ | (115) |
| circABCB10 | hsa_circ_ 0008717 | 724 | ABCB10 | \ | promote cell proliferation, glycolysis, and increase IR resistance | miR-223-3p | PFN2 | (116) |
| circular RNA PVT1 | hsa_circ_0001821 | 410 | PVT1 | cytoplasm | promote tumor growth in vivo | miR-204-5p | upregulate E-cadherin, downregulate N-cadherin, Vimentin, Slug, and Twist | (117) |
| circRAD18 | hsa_circ_0002453 | 756 | RAD18 | cytoplasm | promote cell proliferation and migration, inhibit cell apoptosis in vitro, promote tumor growth in vivo | miR-208a and miR-3164 | IGF1 and FGF2 | (118) |
| circRAD18 | hsa_circ_0002453 | 756 | RAD18 | cytoplasm | promote cell proliferation, migration, invasion, EMT, and inhibit cell apoptosis | miR-613 | HK2 | (119) |
| hsa_circ_0131242 | hsa_circ_0131242 | 12400 | MAP3K4 | \ | promote cell proliferation and migration in vitro | miR-2682 | \ | (120) |
| *hsa_circ_0072995 | hsa_circ_0072995 | 435 | ARHGEF28 | both nucleus and cytoplasm | promote cell migration and invasion | miR-30c-2-3p | ARHGEF28 | (121) |
| circ-TFF1 | hsa_circ_0061825 | 492 | TFF1 | cytoplasm | promote cell proliferation, migration, invasion, EMT in vitro, and tumor growth in vivo | miR-326 | TFF1 | (122) |
| circ_0000291 | hsa_circ_0000291 | 311 | CD44 | \ | promote cell proliferation, migration, and invasion | miR-326 | ETS1 | (123) |
| circular RNA 0007255 | hsa_circ_0007255 | 355 | KIF4A | cytoplasm | promote oxygen consumption, colony formation, and cell mobility in vitro, inhibit tumor growth in vivo | miR-335-5p | SIX2 | (124) |
| circEIF3M | hsa_circ_0003119 | 361 | EIF3M | cytoplasm | promote cell proliferation, migration, and invasion | miR-33a | cyclin D1 | (125) |
| hsa_circRNA_002178 | hsa_circ_0000519 | 98 | RPPH1 | cytoplasm | promote cell proliferation, energy metabolism, and angiogenesis | miR-328-3p | COL1A1 | (126) |
| circ-PGAP3 | hsa_circ_0106800 | 537 | PGAP3 | cytoplasm | promote cell proliferation and invasion | miR-330-3p | Myc | (127) |
| circIRAK3 | hsa_circ_0005505 | 754 | IRAK3 | cytoplasm | promote cell migration and invasion in vitro, promote metastasis and in vivo | miR-3607 | FOXC1 | (128) |
| hsa_circ_0008039 | hsa_circ_0008039 | 462 | PRKAR1B | cytoplasm | promote cell proliferation and migration in vitro | miR-432-5p | E2F3 | (129) |
| hsa_circ_0008039 | hsa_circ_0008039 | 462 | PRKAR1B | \ | promote cell proliferation, migration, and invasion in vitro, and promote tumor growth in vivo | miR-515-5p | CBX4 | (130) |
| circular RNA circ-ZEB1 | \ | \ | \ | \ | promote cell proliferation and inhibit apoptosis | miR-448 | eEF2K | (131) |
| circular RNA-100219 | hsa_circ_0004619 | 377 | FAF1 | \ | promote cell proliferation and migration in vitro | miR-485-3p | NTRK3 | (132) |
| circMYO9B | hsa_circ_0000907 | 898 | MYO9B | \ | promote cell proliferation, migration, and invasion in vitro, and promote tumor growth in vivo | miR-4316 | FOXP4 | (133) |
| circRNF20 | hsa_circ_0087784 | 499 | RNF20 | cytoplasm | promote cell proliferation, inhibit cell apoptosis in vitro, promote tumor growth in vivo | miR-487a | HIF1α-HK2 | (134) |
| hsa_circ_0007534 | hsa_circ_0007534 | 400 | DDX42 | \ | promote cell proliferation, invasion, and inhibit apoptosis in vitro | miR-593 | MUC19 | (135) |
| circ_DCAF6 | \ | \ | \ | cytoplasm | promote cell proliferation and stemness | miR-616-3p | GLI1 | (136) |
| circ_0005230 | hsa_circ_0005230 | 3958 | DNM3OS | \ | promote cell invasion, migration in vitro, and promote cell growth in vivo | miR-618 | CBX8 | (137) |
| circZFR | hsa_circ_0072088 | 693 | ZFR | \ | promote cell proliferation, migration, invasion, glycolysis, and inhibit cell apoptosis in vitro, promote tumor growth in vivo | miR-578 | HIF1A | (138) |
| circ-UBAP2 | hsa_circ_0001846 | 747 | UBAP2 | cytoplasm | promote cell proliferation, migrate, and inhibit cell apoptosis in vitro, and promote tumor growth and metastasis in vivo | miR-66 | MTA1 | (139) |
| circFBXL5 | hsa_circ_0125597 | 912 | FBXL5 | cytoplasm | promote cell proliferation and migration in vitro, promote tumor growth and metastasis in vivo | miR-660 | SRSF6 | (140) |
| circTP63 | \ | 295 | TP63 | cytoplasm | promote cell proliferation, invasion, migration in vitro, promote tumor growth in vivo | miR-873-3p | FOXM1 | (141) |
| hsa_circRPPH1_015 | hsa_circ_0000517 | 88 | RPPH1 | cytoplasm | promote cell proliferation and aggressiveness in vitro, promote tumor growth in vivo | miR-326 | ELK1 | (142) |
| #circANKRD12 | hsa_circ_0046841 or \ | 286 or 925 | ANKRD12 | cytoplasm | promote cell proliferation, invasion, migration, and alter cell metabolism | \ | CCND1 | (143) |
| circCNOT2 | \ | \ | \ | \ | increase cell proliferation | \ | \ | (144) |
| circAMOTL1 | \ | \ | \ | \ | promote cell proliferation and invasion, and inhibit cell apoptosis when exposed to PAX in vitro | \ | AKT | (145) |
| circ_103809 | \ | \ | \ | \ | promote cell proliferation | \ | PI3K/AKT signaling | (146) |
| hsa_circ_0008673 | hsa_circ_0008673 | 689 | BRCA1 | \ | promote cell proliferation and migration | \ | \ | (147) |
| hsa_circ_001569 | \ | \ | \ | \ | promote cell proliferation, migration, invasion, and inhibit cell apoptosis in vitro | \ | PI3K/AKT signaling | (148) |
| circBACH2 | hsa_circ_0001627 | 2995 | BACH2 | cytoplasm | promote cell proliferation, invasion, and migration in vitro, promote tumor growth and metastasis in vivo | miR-186-5p/miR-548c-3p | CXCR4 | (149) |
| circPGR | \ | \ | PGR | cytoplasm | promote ER-positive breast cancer cell proliferation, invasion, and migration in vitro, promote tumor growth in vivo | miR-301a-5p | Cell cycle genes | (150) |
EMT, epithelial mesenchymal transition; PAX, paclitaxel; *The circRNA can simultaneously regulate an miRNA and genes, but the relationship between miRNA and genes is not clear. #Two circular isoforms of 286 bp (hsa_circ_0046841) and 925 bp (not found in the circbase) lengths share the same backsplice junction of ANKRD12, and the study did not distinguish these two circular isoforms.