Table 3.
CircRNAs with tumor suppressive functions in breast cancer.
| CircRNA name | CircBase ID | Length | Gene | Distribution | Phenotype | Target | Downstream genes/ pathways |
Reference |
|---|---|---|---|---|---|---|---|---|
| TV-circRGPD6 | \ | \ | \ | \ | inhibit tumor-initiating properties in vitro, inhibit tumor growth and metastasis in vivo | miR-26b | YAF2 | (152) |
| circ-Ccnb1 | hsa_circ_0072758 | 342 | CCNB1 | nucleus | inhibit cell proliferation, increase cell apoptosis in vitro, inhibit tumor growth and extend mouse viability in vivo | \ | interact with H2AX, p53, and BCLAF1 | (153) |
| circular RNA 000554 | hsa_circ_0000376 | 48782 | PRH1-PRR4 | cytoplasm | inhibit cell invasion and migration in vitro, inhibit tumor growth in vivo | miR-182 | ZFP36 | (155) |
| circRNA_0025202 | hsa_circ_0025202 | 495 | GAPDH | cytoplasm | inhibit cell proliferation, migration, increase cell apoptosis and sensitivity to tamoxifen in HR(+) BC cells in vitro | miR-182-5p | FOXO3a | (156) |
| circular RNA-0001283 | hsa_circ_0001283 | 1400 | WDR48 | cytoplasm | inhibit cell proliferation, invasion, and promote cell apoptosis | miR-187 | HIPK3 | (157) |
| circTADA2A-E6 and circTADA2A-E5/E6 | hsa_circ_0006220 hsa_circ_0043278 | 158 and 250 | TADA2A | cytoplasm | inhibit cell proliferation, migration, invasion in vitro | miR-203a-3p | SOCS | (52) |
| circASS1 | hsa_circ_0089105 | 241 | ASS1 | both nucleus and cytoplasm(majority) | inhibit cell invasion and migration in vitro | miR-4443 | ASS1 | (158) |
| circKDM4C | hsa_circ_0001839 | 292 | KDM4C | cytoplasm | inhibit cell proliferation, invasion, migration, doxorubicin resistance, promote cell apoptosis in vitro, inhibit tumor growth and metastasis, in vivo | miR-548p | PBLD | (53) |
| circBMPR2 | hsa_circ_0003218 | 342 | BMPR2 | cytoplasm | inhibit cell proliferation, migration, and invasion and tamoxifen resistance | miR-553 | USP4 | (159) |
| circular RNA 0001073 | hsa_circ_0001073 | 473 | ACVR2A | both nucleus and cytoplasm | inhibit proliferation, migration, invasion, and promote apoptosis in vitro, inhibit tumor growth in vivo | \ | HuR | (160) |
| circ-Foxo3 | \ | \ | FOXO3 | \ | inhibit tumor growth and extend mouse lifespan in vivo | \ | increase Foxo3 protein level but decreasep53 level | (161) |
| circular RNA−MTO1 | hsa_circ_0007874 | 318 | MTO1 | both nucleus and cytoplasm | inhibit cell proliferation, promote monastrol-induced cell cytotoxicity and reverse monastrol resistance in vitro | \ | TRAF4/Eg5 | (162) |
| circFBXW7 | hsa_circ_0001451 | 1227 | FBXW7 | cytoplasm | inhibit cell proliferation, migration in vitro and inhibit tumor growth and lung metastasis in vivo | miR-197-3p and FBXW7-185aa | FBXW7 | (163) |
| circRNA-000911 | \ | \ | \ | \ | inhibit cell proliferation, migration, and invasion, and promote cell apoptosis | miR−449a | NOTCH1/NF-κB | (59) |
| circEHMT1 | \ | \ | EHMT1 | \ | inhibit cell migration and invasion in vitro and inhibit lung metastasis in vivo | miR-1233-3p | KLF4/MMP2 | (164) |
| circNFIC | hsa_circ_0002018 | 311 | NFIC | cytoplasm | inhibit cell proliferation and migration in vitro, inhibit cell growth and lung metastasis in vivo | miR-658 | UPK1A | (165) |
| circ_0000442 | hsa_circ_0000442 | 7273 | MED13L | \ | inhibit cell proliferation in vitro and inhibit tumor growth in vivo | miR-148b-3p | PTEN/PI3K/AKT | (166) |
| circCDYL | hsa_circ_0008285 | 667 | CDYL | cytoplasm | inhibit cell proliferation, migration, invasion, and promote cell apoptosis | miR-190a-3p | TP53INP1 | (167) |
| circ-ITCH | \ | \ | ITCH | \ | inhibit cell proliferation, migration, and invasion in vitro, and inhibit tumor growth and metastasis in vivo | miR-214 and miR-17 | ITCH | (168) |
| Circular RNA BARD1 | hsa_circ_0001098 | 1204 | BARD1 | \ | inhibit cell proliferation and promote cell apoptosis in vitro, inhibit tumor growth and metastasis in vivo | miR-3942-3p | BARD1 | (169) |
| circAHNAK1 | hsa_circ_0000320 | 384 | AHNAK1 | cytoplasm | inhibit cell proliferation, migration, and invasion in vitro, inhibit tumor growth and metastasis in vivo | miR-421 | RASA1 | (170) |
| hsa_circ_0072309 | hsa_ circ_0072309 | 580 | LIFR | cytoplasm | inhibit cell proliferation, migration, and invasion in vitro, promote tumor growth in vivo | miR-492 | \ | (171) |
| circRNA_103809 | \ | \ | ZFR | \ | inhibit cell proliferation, invasion, and migration, EMT in vitro | miR-532-3p | \ | (172) |
| circDDX17 | hsa_circ_0002211 | 927 | DDX17 | cytoplasm | inhibit cell proliferation and promote cell apoptosis | miR-605 | CDK1 and p21 | (173) |
| hsa_circ_0068033 | hsa_circ_0068033 | 900 | NAALADL2 | cytoplasm | inhibit cell proliferation, invasion, migration, and promote apoptosis in vitro, inhibit tumor growth in vivo | miR-659 | \ | (174) |
| hsa_circ_0001785 | hsa_circ_0001785 | 467 | ELP3 | cytoplasm | inhibit cell proliferation, migration, and invasion in vitro, inhibit tumor growth in vivo | miR-942 | SOCS3 | (175) |
| circSMARCA5 | hsa_circ_0001445 | 269 | SMARCA5 | nucleus | increase cisplatin sensitivity in vitro and in vivo | \ | SMARCA5 | (176) |
| circSCYL2 | hsa_circ_0006258 | 508 | SCYL2 | \ | inhibit cell migration and invasion | \ | EMT | (177) |
| circ-LARP4 | \ | \ | LARP4 | \ | increase the doxorubicin sensitivity in vitro | \ | \ | (178) |
| circular RNA VRK1 | hsa_circ_0141206 | 852 | VRK1 | \ | inhibit cell proliferation, promote cell apoptosis in vitro | \ | \ | (179) |
| circular RNA VRK1 | hsa_circ_0141206 | 852 | VRK1 | cytoplasm | inhibit cell proliferation, promote cell apoptosis, and inhibit self-renewal capacity in vitro | \ | \ | (180) |
| circUSP42 | hsa_circ_0007823 | 451 | USP42 | \ | inhibit cell invasion and migration | miR-4443 | ASS1 | (181) |