Table 4.
CircRNAs with diagnostic and prognostic value in breast cancer.
| CircRNA name | Circbase ID | Clinicopathological Association | Tumor type (Sample number) | Reference |
|---|---|---|---|---|
| circSEPT9 | hsa_circ_0005320 | TNM stage, T stage, N stage, OS, diagnosis | TNBC (cohort2: n=80; cohort1: n=60) | (32) |
| circZNF609 | hsa_circ_0000615 | lymph node metastasis, TNM stage, OS | (n=143) | (74) |
| circHMCU | hsa_circ_0000247 | lymph node metastasis, T stage, N stage, histological grade, OS | (n=267) | (79) |
| circPLK1 | hsa_circ_0038632 | tumor size, lymph node metastasis, TNM stage, DFS, OS | TNBC (n=240) | (81) |
| hsa_circ_0000515 | hsa_circ_0000515 | OS | (n=340) | (82) |
| circWWC3 | hsa_circ_0089866 and hsa_circ_0001910 | clinical stage, OS | (n=156) | (83) |
| circRGPD6 | \ | DFS, OS | (n=165) | (152) |
| circular HER2 | hsa_circ_0007766 | OS | TNBC (n=59) | (86) |
| circRNA_0025202 | hsa_circ_0025202 | lymph node metastasis, histological grade | HR positive breast cancer (n=230) | (156) |
| circular RNA 0001073 | hsa_circ_0001073 | tumor size, distant metastasis, TNM stage, RFS, diagnosis | (n=132) | (160) |
| circFBXW7 | hsa_circ_0001451 | tumor size, lymph node metastasis, DFS, OS | TNBC (n=473) | (163) |
| circular RNA VRK1 | hsa_circ_0141206 | tumor size, TNM stage, T stage, N stage, histological grade, OS, diagnosis | (n=350) | (179) |
| *circIFI30 | hsa_circ_0005571 | clinical stage, histological grade, OS, diagnosis | TNBC (n=78/n=38) | (87) |
| circAGFG1 | hsa_circ_0058514 | TNM stage, T stage, N stage, OS, diagnosis | TNBC (n=40) | (54) |
| hsa_circ_006054, hsa_circ_100219, and hsa_circ_406697 | \ | diagnosis | (n=51) | (55) |
| hsa_circ_0001785 | hsa_circ_0001785 | distant metastasis, TNM stage, histological grade, diagnosis | (n=57) | (182) |
| circKIF4A | hsa_circ_0007255 | tumor size, lymph node metastasis, TNM stage, DFS, OS | TNBC (n=240) | (88) |
| circEPSTI1 | hsa_circ_0000479 | tumor size, lymph node metastasis, TNM stage, DFS, OS | TNBC (n=240) | (56) |
| circGNB1 | hsa_circ_0009362 | tumor size, TNM stage, DFS, OS | TNBC (n=222) | (89) |
| circANKS1B | hsa_circ_0007294 | lymph node metastasis, clinical stage, OS | TNBC (n=165) | (61) |
| hsa_circ_0006220 | hsa_circ_0006220 | lymph node metastasis, pathological type, diagnosis | (n=50) | (65) |
| circGFRA1 | hsa_circ_0005239 | tumor size, lymph node metastasis, TNM stage, DFS, OS | TNBC (n=222) | (90) |
| circRNA_069718 | hsa_circ_0069718 | lymph node metastasis, TNM stage, OS | TNBC (n=35) | (91) |
| hsa_circ_002178 | \ | tumor size, lymph node metastasis, OS | (n=83) | (97) |
| circRNA_100876 | \ | OS | (n=50) | (99) |
| circMMP11 | hsa_circ_0062558 | lymph node, metastasis, TNM stage | (n=113) | (101) |
| circUBE2D2 | \ | tumor size, lymph node metastasis, TNM stage, OS, PFS | (n=80) | (102) |
| circUBE2D2 | hsa_circ_0005728 | lymph node metastasis, TNM stage, OS | TNBC (n=66) | (104) |
| circCDYL | \ | DFS, OS | (n=113) | (108) |
| circ_0000520 | hsa_circ_0000520 | lymph node metastasis, TNM stage, OS | (n=60) | (109) |
| circHIPK3 | hsa_circ_0000284 | lymph node metastasis, TNM stage, OS | (n=50) | (114) |
| hsa_circ_001783 | \ | tumor size, metastasis, TNM stage, DFS | (n=136) | (115) |
| circular RNA PVT1 | hsa_circ_0001821 | TNM stage, OS | (n=99) | (117) |
| circRAD18 | hsa_circ_0002453 | tumor size, TNM stage, T stage, OS | TNBC (n=126) | (118) |
| hsa_circ_0131242 | hsa_circ_0131242 | tumor size, TNM stage, OS | TNBC (n=86) | (120) |
| circ_0000291 | hsa_circ_0000291 | tumor size, lymph node metastasis | (n=37) | (123) |
| hsa_circRNA_002178 | hsa_circ_0000519 | OS | (n=70) | (126) |
| circ-PGAP3 | hsa_circ_0106800 | tumor size, lymph node metastasis, TNM stage, DFS,OS | TNBC (n=86) | (127) |
| circIRAK3 | hsa_circ_0005505 | RFS | (n=122) | (128) |
| circMYO9B | hsa_circ_0000907 | tumor size, lymph node metastasis, TNM stage, OS | (n=21) | (133) |
| circRNF20 | hsa_circ_0087784 | tumor size, lymph node metastasis, OS | (n=50) | (134) |
| circZFR | hsa_circ_0072088 | TNM stage, OS | (n=70) | (138) |
| circ-UBAP2 | hsa_circ_0001846 | tumor size, lymph node metastasis, distant metastasis, TNM stage, OS | TNBC (n=78) | (139) |
| circFBXL5 | hsa_circ_0125597 | OS | (n=150) | (140) |
| circCNOT2 | \ | PFS | (n=84) | (144) |
| hsa_circ_001569 | \ | lymph node metastasis, clinical stage, OS | (n=75) | (148) |
| circBACH2 | hsa_circ_0001627 | T stage, N stage, TNM stage | TNBC (n=38) | (149) |
| circNFIC | hsa_circ_0002018 | lymph node metastasis, OS | (n=145) | (165) |
| circAHNAK1 | hsa_circ_0000320 | TNM stage, T stage, N stage, DFS, OS | TNBC (n=136) | (170) |
| hsa_circ_0072309 | hsa_circ_0072309 | tumor size, lymph node metastasis, TNM stage, OS | (n=32) | (171) |
| circRNA_103809 | \ | distant metastasis, TNM stage, OS, HER2 status | (n=65) | (172) |
| circDDX17 | hsa_circ_0002211 | lymph node metastasis, TNM stage | \ | (173) |
| hsa_circ_0068033 | hsa_circ_0068033 | tumor size, lymph node metastasis, diagnosis | (n=36) | (174) |
| circ-LARP4 | \ | tumor size, TNM stage, T stage, N stage, DFS, OS | (n=283) | (178) |
| circUSP42 | hsa_circ_0007823 | lymph node metastasis, TNM stage, DFS, OS | TNBC (n=30) | (181) |
TNM, tumor node metastasis; DFS, disease free survival; PFS, progression free survival; OS, overall survival; *n = 78 for the study of relationships between circIFI30 expression and clinical stage, histological grade and OS, while n = 38 for the study of the diagnostic value of circIFI30.