TABLE 1.
Distribution and antifungal susceptibility of C. tropicalis by clinical services and specimen types.
| Characters |
No. of isolates (%) |
Antifungal susceptibility (%) |
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| CHIF-NET 10–18 | CHIF-NET 15–18 |
Fluconazolea |
Voriconazolea |
Itraconazoleb |
Posaconazoleb |
Caspofunginb |
Micafunginb |
Anidulafunginb |
5-Flucytosineb |
Amphotericin Bb |
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| S | R | S | R | WT | NWT | WT | NWT | S | R | S | R | S | R | WT | NWT | WT | NWT | |||
| Overall | 3702 (100.0) | 2192 (100.0) | 71.2 | 22.2 | 63.8 | 20.3 | 83.1 | 16.9 | 28.3 | 71.7 | 99.0 | 0.7 | 99.0 | 0.8 | 97.6 | 0.6 | 99.0 | 1.0 | 99.8 | 0.2 |
| Clinical service | ||||||||||||||||||||
| Inpatient | 3491 (94.3) | 2070 (94.4) | 71.4 | 22.1 | 63.8 | 20.1 | 83.1 | 16.9 | 28.5 | 71.5 | 98.9 | 0.7 | 99.0 | 0.8 | 97.5 | 0.6 | 99.0 | 1.0 | 99.8 | 0.2 |
| Medical | 1110 (30.0) | 703 (32.1) | 65.7 | 28.1 | 58.5 | 26.5 | 76.4 | 23.6 | 26.9 | 73.1 | 98.9 | 0.9 | 98.9 | 0.9 | 97.6 | 1.0 | 99.4 | 0.6 | 99.4 | 0.6 |
| ICU | 1092 (29.5) | 618 (28.2) | 74.3 | 19.6 | 67.9 | 17.9 | 87.2 | 12.8 | 31.4 | 68.6 | 98.9 | 0.6 | 99.0 | 0.8 | 96.8 | 0.5 | 99.5 | 0.5 | 99.8 | 0.2 |
| Surgical | 1086 (29.3) | 649 (29.6) | 74.2 | 17.9 | 65.4 | 15.4 | 86.7 | 13.3 | 28.4 | 71.6 | 99.2 | 0.3 | 99.4 | 0.5 | 98.3 | 0.3 | 98.2 | 1.8 | 100.0 | 0.0 |
| Other | 203 (5.5) | 100 (4.6) | 71.4 | 24.6 | 63.1 | 22.7 | 82.0 | 18.0 | 22.0 | 78.0 | 98.0 | 2.0 | 98.0 | 2.0 | 97.0 | 1.0 | 98.0 | 2.0 | 100.0 | 0.0 |
| Emergency department | 162 (4.4) | 100 (4.6) | 65.4 | 26.5 | 58.0 | 26.5 | 84.0 | 16.0 | 24.0 | 76.0 | 99.0 | 1.0 | 99.0 | 1.0 | 99.0 | 1.0 | 99.0 | 1.0 | 100.0 | 0.0 |
| Outpatient | 49 (1.3) | 22 (1.0) | 79.6 | 20.4 | 77.6 | 16.3 | 77.3 | 22.7 | 31.8 | 68.2 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 |
| Specimen type | ||||||||||||||||||||
| Blood | 1799 (48.6) | 1122 (51.2) | 66.7 | 27.2 | 58.6 | 25.6 | 79.4 | 20.6 | 27.1 | 72.9 | 98.8 | 0.9 | 98.8 | 0.9 | 97.2 | 1.0 | 99.2 | 0.8 | 99.7 | 0.3 |
| Non-blood samples | 1903 (51.4) | 1070 (48.8) | 75.5 | 17.6 | 68.7 | 15.4 | 87.0 | 13.0 | 29.5 | 70.5 | 99.2 | 0.5 | 99.3 | 0.7 | 98.0 | 0.3 | 98.8 | 1.2 | 99.8 | 0.2 |
| Ascitic fluid | 708 (19.1) | 373 (17.0) | 77.5 | 15.8 | 71.6 | 13.8 | 87.7 | 12.3 | 28.7 | 71.3 | 98.9 | 0.5 | 99.2 | 0.8 | 98.1 | 0.3 | 98.7 | 1.3 | 99.7 | 0.3 |
| Pus | 344 (9.3) | 205 (9.4) | 74.4 | 17.7 | 67.4 | 16.0 | 83.4 | 16.6 | 32.7 | 67.3 | 100.0 | 0.0 | 100.0 | 0.0 | 99.0 | 0.0 | 99.5 | 0.5 | 99.5 | 0.5 |
| Bile | 216 (5.8) | 143 (6.5) | 72.7 | 21.3 | 62.5 | 18.1 | 86.7 | 13.3 | 29.4 | 70.6 | 98.6 | 1.4 | 98.6 | 1.4 | 98.6 | 0.7 | 100.0 | 0.0 | 100.0 | 0.0 |
| Pleural fluid | 142 (3.8) | 80 (3.6) | 77.5 | 15.5 | 72.5 | 12.7 | 92.5 | 7.5 | 41.3 | 58.8 | 98.8 | 0.0 | 100.0 | 0.0 | 98.8 | 0.0 | 97.5 | 2.5 | 100.0 | 0.0 |
| CVC | 205 (5.5) | 108 (4.9) | 71.2 | 19.5 | 65.9 | 17.6 | 86.1 | 13.9 | 23.1 | 76.9 | 98.1 | 0.9 | 98.1 | 1.9 | 95.4 | 0.9 | 98.1 | 1.9 | 100.0 | 0.0 |
| BALF | 126 (3.4) | 79 (3.6) | 70.6 | 20.6 | 62.7 | 17.5 | 88.6 | 11.4 | 27.8 | 72.2 | 100.0 | 0.0 | 100.0 | 0.0 | 96.2 | 0.0 | 98.7 | 1.3 | 100.0 | 0.0 |
| Tissue | 70 (1.9) | 38 (1.7) | 80.0 | 17.1 | 72.9 | 14.3 | 89.5 | 10.5 | 23.7 | 76.3 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 |
| CSF | 65 (1.8) | 31 (1.4) | 76.9 | 18.5 | 70.8 | 18.5 | 83.9 | 16.1 | 29.0 | 71.0 | 100.0 | 0.0 | 100.0 | 0.0 | 100.0 | 0.0 | 96.8 | 3.2 | 100.0 | 0.0 |
| Other | 27 (0.7) | 13 (0.6) | 85.2 | 11.1 | 70.4 | 11.1 | 92.3 | 7.7 | 15.4 | 84.6 | 100.0 | 0.0 | 100.0 | 0.0 | 92.3 | 0.0 | 92.3 | 7.7 | 100.0 | 0.0 |
S, susceptible; R, resistant; WT, wild-type; NWT, non-wild-type; ICU, intensive care unit.
aFor isolates from CHIF-NET10–18.
bFor isolates from CHIF-NET15–18.