Table 3.
Self-Report Mood, Anxiety, and Personality Scores as a Function of Carrier Status
| Gene: APOE | ε4+ n=31 | ε4− n=117 | p | ηp2 |
|---|---|---|---|---|
| Beck | ||||
| Depression (BDI-II) | 11.0 (3.0–20.0) | 12.0 (5.5–20.5) | 0.627 | 0.003 |
| Anxiety (BAI)* | 11.0 (2.0–19.0) | 10.0 (4.0–18.0) | 0.875 | 0.000 |
| PAI± | ||||
| Somatic Concerns | 63.2 (8.8) | 62.6 (8.8) | 0.231 | 0.017 |
| Anxiety | 55.9 (10.2) | 55.6 (10.2) | 0.572 | 0.004 |
| Depression | 57.5 (11.0) | 57.4 (11.3) | 0.948 | 0.000 |
| Mania | 45.2 (7.6) | 44.6 (7.6) | 0.117 | 0.029 |
| Paranoia | 49.0 (43.3–59.0) | 46.0 (40.0–56.0) | 0.361 | 0.009 |
| Schizophrenia | 51.3 (9.0) | 51.6 (9.3) | 0.569 | 0.004 |
| Borderline Features | 50.7 (9.1) | 50.5 (9.2) | 0.634 | 0.003 |
| Antisocial Features | 48.5 (40.8–54.0) | 45.0 (41.0–52.0) | 0.466 | 0.010 |
| Alcohol Problems | 47.0 (41.0–47.8) | 45.0 (41.0–50.0) | 0.834 | 0.000 |
| Drug Problems | 48.0 (42.0–52.5) | 48.0 (45.0–54.0) | 0.418 | 0.005 |
| Gene: BDNF | Met+ n=47 | Met− n=101 | p | ηp2 |
| Beck | ||||
| Depression (BDI-II) | 15.5 (6.0–21.0) | 12.0 (5.0–21.0) | 0.196 | 0.004 |
| Anxiety (BAI)* | 12.5 (5.8–19.0) | 9.0 (3.0–17.0) | 0.184 | 0.006 |
| PAI± | ||||
| Somatic Concerns | 64.2 (8.8) | 62.8 (8.8) | 0.552 | 0.004 |
| Anxiety | 59.6 (9.6) | 54.7 (10.2) | 0.050 | 0.045 |
| Depression | 63.3 (10.2) | 55.5 (10.7) | 0.004 | 0.095 |
| Mania | 45.1 (8.4) | 45.2 (7.4) | 0.954 | 0.000 |
| Paranoia | 50.0 (45.0–56.5) | 45.0 (40.0–57.0) | 0.132 | 0.020 |
| Schizophrenia | 52.4 (7.3) | 51.0 (9.5) | 0.529 | 0.005 |
| Borderline Features | 53.5 (9.1) | 49.8 (9.0) | 0.108 | 0.030 |
| Antisocial Features | 45.5 (40.8–53.3) | 45.0 (41.0–52.0) | 0.910 | 0.001 |
| Alcohol Problems | 47.0 (41.0–50.0) | 45.0 (41.0–48.0) | 0.467 | 0.002 |
| Drug Problems | 48.0 (42.0–51.0) | 48.0 (45.0–55.0) | 0.137 | 0.031 |
| Gene: COMT | Val+ n=110 | Val− n=38 | p | ηp2 |
| Beck | ||||
| Depression (BDI-II) | 14.5 (6.0–21.3) | 10.0 (4.0–17.0) | 0.087 | 0.022 |
| Anxiety (BAI)* | 11.0 (5.0–19.0) | 5.0 (2.0–15.0) | 0.081 | 0.027 |
| PAI± | ||||
| Somatic Concerns | 63.7 (9.4) | 61.8 (9.2) | 0.760 | 0.001 |
| Anxiety | 57.2 (10.4) | 52.3 (8.8) | 0.054 | 0.043 |
| Depression | 58.6 (10.8) | 54.1 (11.1) | 0.245 | 0.016 |
| Mania | 44.6 (7.2) | 47.1 (8.6) | 0.183 | 0.021 |
| Paranoia | 49.0 (40.5–58.0) | 44.5 (37.8–51.8) | 0.097 | 0.027 |
| Schizophrenia | 52.8 (9.2) | 46.8 (7.0) | 0.007 | 0.083 |
| Borderline Features | 51.7 (9.2) | 48.0 (8.4) | 0.292 | 0.013 |
| Antisocial Features | 48.0 (42.0–53.0) | 42.0 (38.0–51.3) | 0.038 | 0.039 |
| Alcohol Problems | 47.0 (41.0–50.0) | 42.0 (41.0–47.0) | 0.031 | 0.033 |
| Drug Problems | 48.0 (46.0–54.0) | 48.0 (42.0–54.0) | 0.379 | 0.007 |
*
n=129; ε4+ 28, ε4− 101
±
n=87; ε4+ 18, ε4− 69
*
n=129; Met+ 42, Met− 87
±
n=87; Met+ 22, Met− 65
*
n=129; Val+ 102, Val− 27
±
n=87; Val+ 65, Met− 22
Note: BDI-II and BAI scores are reported as raw scores; PAI scores are reported as t-scores (M=50, SD=10)
Values reported as mean (SD) for normally distributed variables and median (IQR) reported for skewed variables.