Table 4.

Proportion of Patients with Clinically Elevated Scores on Self-Report Measures

Gene: APOE	ε4+ n=31	ε4− n=117	p	Cramer’s V
Beck
Depression (BDI-II)	14 (45)	56 (48)	0.842	0.022
Anxiety (BAI)*	16 (57)	59 (59)	1.000	0.011
PAI±
Somatic Concerns	13 (72)	38 (55)	0.283	0.141
Anxiety	8 (44)	20 (29)	0.260	0.134
Depression	6 (33)	29 (42)	0.595	0.072
Mania	2 (11)	7 (10)	1.000	0.013
Paranoia	4 (22)	9 (13)	0.456	0.104
Schizophrenia	2 (11)	14 (20)	0.506	0.096
Borderline Features	2 (11)	11 (16)	1.000	0.055
Antisocial Features	2 (11)	4 (6)	0.599	0.085
Alcohol Problems	1 (6)	2 (3)	0.506	0.059
Drug Problems	3 (17)	11 (16)	1.000	0.008
Gene: BDNF	Met+ n=47	Met− n=101	p	Cramer’s V
Beck
Depression (BDI-II)	27 (57)	43 (43)	0.112	0.139
Anxiety (BAI)*	28 (67)	47 (54)	0.188	0.120
PAI±
Somatic Concerns	14 (64)	37 (57)	0.625	0.059
Anxiety	10 (46)	18 (28)	0.186	0.165
Depression	13 (59)	22 (34)	0.046	0.224
Mania	6 (9)	3 (14)	0.686	0.063
Paranoia	3 (14)	10 (15)	1.000	0.021
Schizophrenia	3 (14)	13 (20)	0.751	0.071
Borderline Features	4 (18)	9 (14)	0.731	0.053
Antisocial Features	3 (14)	3 (5)	0.167	0.155
Alcohol Problems	0 (0)	3 (5)	0.568	0.110
Drug Problems	1 (5)	13 (20)	0.106	0.183
Gene: COMT	Val+ n=110	Val− n=38	p	Cramer’s V or OR**
Beck
Depression (BDI-II)	58 (53)	12 (32)	0.209	0.612**
Anxiety (BAI)*	64 (63)	11 (41)	0.097	0.476**
PAI±
Somatic Concerns	39 (60)	12 (55)	0.997	1.002**
Anxiety	25 (39)	3 (14)	0.036	0.231
Depression	28 (43)	7 (32)	0.487	0.689**
Mania	6 (9)	3 (14)	0.686	0.063
Paranoia	2 (9)	11 (17)	0.502	0.095
Schizophrenia	15 (23)	1 (5)	0.061	0.208
Borderline Features	2 (9)	11 (17)	0.641	0.675**
Antisocial Features	5 (8)	1 (5)	1.000	0.054
Alcohol Problems	1 (5)	2 (3)	1.000	0.035
Drug Problems	10 (15)	4 (18)	0.745	0.033

^*n=129; ε4+ 28, ε4− 101

^±n=87; ε4+ 18, ε4− 69

^*n=129; Met+ 42, Met− 87

^±n=87; Met+ 22, Met− 65

^*n=129; Val+ 102, Val− 27

^±n=87; Val+ 65, Met− 22

BDI-II=Beck Depression Inventory – Second Edition; BAI=Beck Anxiety Inventory; OR = odds ratio Exp(B)

Values reported as n (%).