Table 1.
Patients’ characteristics.
| ALL | Type-II dominant | Type-III dominant | p value | ||
|---|---|---|---|---|---|
| Overall | N | 60 | 13 (21%) | 47 (79%) | |
| Gender | F | 33 (55%) | 9 (69%) | 24 (51%) | |
| M | 27 (45%) | 4 (31%) | 23 (49%) | 0.348 | |
| Age | 37 [5–84] | 39 [15–80] | 36 [5–84] | 0.501 | |
| Diagnosis | pPNH | 28 (46%) | 4 (30%) | 24 (51%) | |
| sPNH | 32 (53%) | 9 (70%) | 23 (49%) | 0.348 | |
| Granulocytes clone size (%)a | 71.49 (21.5–99.9) | 69.5 (21.5–99.5) | 78.2 (22.1–99.9) | 0.872 | |
| Type II RBC clone size (%)a | 2.41 (0–84.6) | 40.9 (6.8–84.1) | 1.9 (0.54–30) | ||
| Type III RBC clone size (%)a | 14.75 (0–93.4) | 3.2 (1.2–21.8) | 22.1 (11.4–93.4) | ||
| Hb (gr/dl) at diagnosisa | 9.9 [8–11] | 9.3 (8.3–10.45) | 10(8.1–11.4) | 0.452 | |
| ANC (109/L) diagnosisa | 2 (1.19–3) | 2.4 (1.17–2.85) | 2 (1.27–3.05) | 0.98 | |
| PLT (109/L) at diagnosisa | 68 (5–241) | 37 (15–148) | 87 (5–241) | 0.085 | |
| LDH (U/L) at diagnosisa | 498 (170–3666) | 346 (170–939) | 571 (196–3666) | 0.015 | |
| Median Follow-up (months) | 102.7 (0.5–375) | 82.3 (11–328) | 109 (0.5–375) |
a
All values are expressed in median (ranges).
F female, M male, RBC red blood cells, Hb hemoglobin, ANC absolute neutrophils count, PLT platelets, pPNH primary paroxysmal nocturnal hemoglobinuria, sPNH secondary paroxysmal nocturnal hemoglobinuria, LDH lactate dehydrogenase.