TABLE 1.

The repulsive ramping scheme used by legacy FastDesign and our new parameterized set of weights, MonomerDesign2019

Round	1a	1b	2a	2b	3a	3b	4a	4b
Legacy	0.02	0.02	0.25	0.25	0.55	0.55	1.00	1.00
MonomerDesign2019	0.06	0.09	0.28	0.32	0.57	0.63	1.00	1.00

Note: Side chain optimization steps (ie, “Packing”) are labeled with an “a,” minimization steps (gradient-based minimization of backbone and side chain torsion angles) are labeled with a “b.” Each step is annotated with the relative repulsive weight for that round, where a value of 1.0 is equal to the weight used for the default Rosetta score function (ref2015).²⁰