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. 2021 Jul 23;20:96. doi: 10.1186/s12943-021-01388-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Differentially expressed urine extracellular vesicle circRNAs between individuals with benign prostatic hyperplasia and those with high-grade prostate cancer using RNA sequencing. (A) In the clustered heatmap, each column represents an individual sample, and each row represents an individual circRNA. The expression values were log2 transformed. (B) Eighteen candidate circRNAs displaying higher levels in patients with high-grade prostate cancer than those with benign prostatic hyperplasia according to the criteria using |fold changes|≥ 2.0 with p values < 0.05. circRNAs = circular RNAs