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. 2021 Jul 9;12:686155. doi: 10.3389/fimmu.2021.686155

Table 4.

NcRNAs targets in rheumatoid arthritis.

NcRNAs Expression Tissue Signalings Phases References
miRNAs
miR-138 Up FLS NF-κB signaling Cell culture (192)
miR-34a-3p Down FLS Animal study (193)
miR-23b Up FLS, STs (31)
miR-125 Down ST PI3K/Akt/mTOR pathway Cell culture (194)
miR-27b-3p Down ST HIPK2 signaling Cell culture (195)
MiR-19a-3p Up ST IGFBP5 signaling Cell culture (196)
Down Plasma SOCS3 Cell culture (197)
miR-142-3p Up ST, FLS NF-κB signaling Cell culture (198)
miRNA‐135a Up ST PI3K/AKT pathway Cell culture (199)
miR-192-5p Down BM-MSC-exos (200)
miR-98 Up FLS IL-10 signaling Cell culture (201)
miR-129-5p Down FLS IGF-1R/SRC/ERK/EGR-1 pathway Cell culture (202)
miR-26a-5p Up FLS PTEN/PI3K/AKT pathway Cell culture (203)
miR-221/222 Up PBMC (204)
miR-191 Up FLS miR-191-C/EBPβ pathway Cell culture (205)
miR-449a Down ST HMGB1 signaling Cell culture (206)
miR-410-3p Down SF, FLS NF-κB signaling Cell culture (207)
miR-506 Down ST, FLS TLR4 signaling Cell culture (208)
miR-320a Down ST MAPK-ERK1/2 pathway Cell culture (209)
miR-29b Up PBM HBP1 signaling Cell culture (210)
miR-155 Up ST FOXO3a signaling Cell culture (211)
miR−145−5p Up FLS NF−κB pathway Animal study (212)
miR-22 Down FLS IL6R signaling/NF-κB pathway Cell culture (213)
Down ST SIRT1 signaling Cell culture (214)
miRNA-141-3p Down FLS FoxC1/β-catenin axis Animal culture (215)
miR-101-3p Down FLS PTGS2 signaling Cell culture (216)
miR-495 Down FLS β-catenin pathway Cell culture (217)
miRNA-17-5p Down FLS JAK/STAT pathway Animal study (218)
miRNA-140-5p Down FLS STAT3 signaling Cell culture (219)
miR-3926 Down FLS TLR 5 signaling Cell culture (220)
miR-613 Down FLS, ST DKK1 signaling Cell culture (221)
miR-15 Up FLS NF-κB pathway Cell culture (222)
miR-21 Down FLS Wnt pathway Animal study (223)
miRNA-15a/16 Down FLS SOX5 axis Cell culture (224)
miRNA-155 Up FLS (225)
miR-26a Down CT, AC CTGF signaling Animal study (226)
miR-106b Down SFDE PDK4 signaling Cell culture (227)
miR-223 Up FLS (228)
miR-411 Down ST, FLS NF-κB pathway Animal study (229)
miR-9 Down FLS NF-κB1-RANKL pathway Animal study (230)
miRNA-486-5p Down FLS-exos Tob1/BMP/Smad pathway Animal study (231)
miR-49 Up PBMC (232)
miR-326 Down PBMC (232)
miR-34a-5p Down ST XBP1 signaling Cell culture (233)
miR-20a Down FLS ADAM10 signaling Cell culture (234)
miR-145-5p Down FLS Wnt1/β-catenin pathway Cell culture (235)
miR-365 Down FLS IGF1 signaling or PI3K/AKT/mTOR pathway Animal study (236)
miR-34a Down BM-MSC-Evs cyclin I/ATM/ATR/p53 axis Cell culture (237)
miR-124a Down FLS PIK3/NF-κB pathway Cell culture (238)
miR-9-5p Down Serum REST/miR-132 pathway Cell culture (239)
miR-34a-5p Down ST XBP1 signaling Cell culture (233)
lncRNAs
linc01197 Down ST miRNA-150/THBS2 axis Cell culture (240)
lncRNA NEAT1 Up PBMC- exos miRNA-23a/MDM2/SIRT6 Axis Cell culture (241)
Up ST, FLS miR-204-5p signaling Cell culture (242)
Up ST, FLS MAPK/ERK pathway Cell culture (243)
Up FLS miR-410-3p/YY1 axis Cell culture (244)
lncRNA PVT1 Up FLS miRNA-145-5p Cell culture (245)
Up ST miR-543-dependent SCUBE2 Cell culture (246)
Up FLS SIRT6 Cell culture (247)
lncRNA OIP5-AS1 Down FLS miR-448-PON1/TLR3/NF-κB axis Cell culture (248)
lncRNA ZFAS1 Up FLS miR-296-5p/MMP-15 Animal study (249)
Up FLS miR-2682-5p/ADAMTS9 axis Cell culture (250)
linc00152 Up FLS Wnt/β-catenin pathway Cell culture (251)
lncRNA MALAT1 Down PBMC Notch pathway Cell culture (252)
lncRNA GAS5 Down FLS miR-128-3p/HDAC4 axis Cell culture (253)
Down ST, FS HIPK2 signaling Cell culture (254)
lncRNA HAND2-AS1 Down MSC-exos miR-143-3p/TNFAIP3/NF-κB pathway Cell culture (255)
lncRNAS56464.1 Up FLS miR−152−3p/Wnt pathway Cell culture (256)
lncRNA PICSAR Up FLS miRNA-4701-5p signaling Cell culture (257)
lncRNA MEG3 Down FLS miR-141/AKT/mTOR pathway Animal study (258)
lncRNA ITSN1-2 Up FLS NOD2/RIP2 pathway Cell culture (259)
lncAL928768.3 Up FLS (260)
lncAC091493.1 Up FLS (260)
lncRNA HOTTIP Up FLS SFRP1 demethylation Cell culture (261)
lncRNA HIX003209 Up PBMC TLR4/NF-κB pathway Cell culture (262)
lncRNA FER1L4 Down ST, FLS NLRC5 signaling Cell culture (263)
lncRNA CASC2 Down Plasma IL−17 signaling Cell culture (264)
lncRNA PlncRNA-1 Down Serum, SF TGF-β1 signaling Cell culture (265)
lncRNA H19 Up FLS Notch pathway Cell culture (266)
Up FLS miR-124a Animal study (267)
lncRNA RP11-83J16.1 Down FLS β-catenin pathway Cell culture (268)
lncRNA H19 Down FLS NF-κB and JNK/p38 MAPK pathways Cell culture (269)
lncRNA XIST Up CT STAT3 signaling Animal study (270)
lncRNA SNHG1 Up FLS PTBP1 signaling Cell culture (271)
lncRNA THRIL Up Serum PI3K/AKT pathway Cell culture (272)
circRNAs
circ_0088036 Up FLS miR-140-3p/SIRT 1 axis Cell culture (273)
circ_0000396 Down FLS miR-203/HBP1 axis Cell culture (274)
circ_AFF2 Up FLS miR-375/TAB2 axis Cell culture (275)
circ_0130438 Down PBMC (276)
circ_0002715 Up PB (277)
circ_0035197 Up PB (277)
circRNA_09505 Up PBMC miR-6089/AKT1/NF-κB axis Animal study (278)
circFADS2 Down AC miR-498/mTOR pathway Cell culture (279)
circ_0000175 Down PBMC (280)
Circ_0008410 Up PBMC (280)

FLS, fibroblast-like synoviocytes; CT, cartilage tissues; AC, articular chondrocytes; ST, synovial tissues; BM-MSC-Evs, bone marrow mesenchymal stem cell -derived extracellular vesicles; MSC-exos, mesenchymal stem cell-derived exosomes; PB, peripheral blood; FoxC1, forkhead box C1; PTGS2, prostaglandin-endoperoxide synthase 2; SOX5, sex determining region Y-box protein 5; CTGF, connective tissue growth factor; SFDE, synovial fibroblast-derived exosomes; PDK4, pyruvate dehydrogenase kinase 4; NF-ΚB, nuclear factor kappa-B; RANKL, receptor activator of nuclear factor-kb ligand; MDM2, murine double minute-2; SIRT6, sirtuin 6; TLR3, toll-like receptor 3; BMP, bone morphogenetic protein; Smad, mouse signal transduction molecule; MMP-15, matrix metalloproteinase 15; XBP1, X-box binding protein 1; Wnt, wingless and integration-1; ADAM, a disintegrin and metalloprotease 10; SCUBE2, signal peptide-CUB-EGF-like containing protein 2; MAPK, mitogen-activated protein kinase; ERK, extracellular regulated protein kinase; HBP1, HMG-box transcription factor 1; HDAC4, histone deacetylase 4; TNFAIP3, tumor necrosis factor alpha-inducible protein 3; TAB2, TAK1-binding 2; ATM, ataxia‐telangiectasia mutated; ATR, ATM-Rad3-related; JAK, janus kinase; STAT, signal transducers and activators of transcription; TLR 5, toll-like receptor 5; DDK1, dickkopf 1; PI3K, phosphatidylinositol 3-kinase; REST, presentational state transfer; PBM, peripheral blood monocytes; FOXO3a, forkhead box O3 alpha; SIRT6, sirtuin 6; HMGB1, high-mobility group box protein 1; C/EBPβ, CCAAT enhancer-binding proteinβ; IGF-1R, insulin-like growth factor 1 receptor; HIPK2, homeodomain-interacting protein kinase 2; SOCS 3, suppressors of cytokine signaling 3; NOD2, nucleotide-binding oligomerization domain 2; RIPK2, receptor interacting serine threonine kinase 2; NLRC5, nucleotide oligomerisation domain-like receptors 5; TGF-b1, transforming growth factor beta 1; PTBP1, polypyridine tract-binding protein 1; HIPK2, homeodomain-interacting protein kinase 2; THBS2, thrombospondin 2; PBMC, peripheral blood monouclear cell; exos: exosomes; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9; mTOR, mammalian target of rapamycinMammalian target of rapamycin.