Table 4.
NcRNAs | Expression | Tissue | Signalings | Phases | References |
---|---|---|---|---|---|
miRNAs | |||||
miR-138 | Up | FLS | NF-κB signaling | Cell culture | (192) |
miR-34a-3p | Down | FLS | – | Animal study | (193) |
miR-23b | Up | FLS, STs | – | – | (31) |
miR-125 | Down | ST | PI3K/Akt/mTOR pathway | Cell culture | (194) |
miR-27b-3p | Down | ST | HIPK2 signaling | Cell culture | (195) |
MiR-19a-3p | Up | ST | IGFBP5 signaling | Cell culture | (196) |
Down | Plasma | SOCS3 | Cell culture | (197) | |
miR-142-3p | Up | ST, FLS | NF-κB signaling | Cell culture | (198) |
miRNA‐135a | Up | ST | PI3K/AKT pathway | Cell culture | (199) |
miR-192-5p | Down | BM-MSC-exos | – | – | (200) |
miR-98 | Up | FLS | IL-10 signaling | Cell culture | (201) |
miR-129-5p | Down | FLS | IGF-1R/SRC/ERK/EGR-1 pathway | Cell culture | (202) |
miR-26a-5p | Up | FLS | PTEN/PI3K/AKT pathway | Cell culture | (203) |
miR-221/222 | Up | PBMC | – | – | (204) |
miR-191 | Up | FLS | miR-191-C/EBPβ pathway | Cell culture | (205) |
miR-449a | Down | ST | HMGB1 signaling | Cell culture | (206) |
miR-410-3p | Down | SF, FLS | NF-κB signaling | Cell culture | (207) |
miR-506 | Down | ST, FLS | TLR4 signaling | Cell culture | (208) |
miR-320a | Down | ST | MAPK-ERK1/2 pathway | Cell culture | (209) |
miR-29b | Up | PBM | HBP1 signaling | Cell culture | (210) |
miR-155 | Up | ST | FOXO3a signaling | Cell culture | (211) |
miR−145−5p | Up | FLS | NF−κB pathway | Animal study | (212) |
miR-22 | Down | FLS | IL6R signaling/NF-κB pathway | Cell culture | (213) |
Down | ST | SIRT1 signaling | Cell culture | (214) | |
miRNA-141-3p | Down | FLS | FoxC1/β-catenin axis | Animal culture | (215) |
miR-101-3p | Down | FLS | PTGS2 signaling | Cell culture | (216) |
miR-495 | Down | FLS | β-catenin pathway | Cell culture | (217) |
miRNA-17-5p | Down | FLS | JAK/STAT pathway | Animal study | (218) |
miRNA-140-5p | Down | FLS | STAT3 signaling | Cell culture | (219) |
miR-3926 | Down | FLS | TLR 5 signaling | Cell culture | (220) |
miR-613 | Down | FLS, ST | DKK1 signaling | Cell culture | (221) |
miR-15 | Up | FLS | NF-κB pathway | Cell culture | (222) |
miR-21 | Down | FLS | Wnt pathway | Animal study | (223) |
miRNA-15a/16 | Down | FLS | SOX5 axis | Cell culture | (224) |
miRNA-155 | Up | FLS | – | – | (225) |
miR-26a | Down | CT, AC | CTGF signaling | Animal study | (226) |
miR-106b | Down | SFDE | PDK4 signaling | Cell culture | (227) |
miR-223 | Up | FLS | – | – | (228) |
miR-411 | Down | ST, FLS | NF-κB pathway | Animal study | (229) |
miR-9 | Down | FLS | NF-κB1-RANKL pathway | Animal study | (230) |
miRNA-486-5p | Down | FLS-exos | Tob1/BMP/Smad pathway | Animal study | (231) |
miR-49 | Up | PBMC | – | – | (232) |
miR-326 | Down | PBMC | – | – | (232) |
miR-34a-5p | Down | ST | XBP1 signaling | Cell culture | (233) |
miR-20a | Down | FLS | ADAM10 signaling | Cell culture | (234) |
miR-145-5p | Down | FLS | Wnt1/β-catenin pathway | Cell culture | (235) |
miR-365 | Down | FLS | IGF1 signaling or PI3K/AKT/mTOR pathway | Animal study | (236) |
miR-34a | Down | BM-MSC-Evs | cyclin I/ATM/ATR/p53 axis | Cell culture | (237) |
miR-124a | Down | FLS | PIK3/NF-κB pathway | Cell culture | (238) |
miR-9-5p | Down | Serum | REST/miR-132 pathway | Cell culture | (239) |
miR-34a-5p | Down | ST | XBP1 signaling | Cell culture | (233) |
lncRNAs | |||||
linc01197 | Down | ST | miRNA-150/THBS2 axis | Cell culture | (240) |
lncRNA NEAT1 | Up | PBMC- exos | miRNA-23a/MDM2/SIRT6 Axis | Cell culture | (241) |
Up | ST, FLS | miR-204-5p signaling | Cell culture | (242) | |
Up | ST, FLS | MAPK/ERK pathway | Cell culture | (243) | |
Up | FLS | miR-410-3p/YY1 axis | Cell culture | (244) | |
lncRNA PVT1 | Up | FLS | miRNA-145-5p | Cell culture | (245) |
Up | ST | miR-543-dependent SCUBE2 | Cell culture | (246) | |
Up | FLS | SIRT6 | Cell culture | (247) | |
lncRNA OIP5-AS1 | Down | FLS | miR-448-PON1/TLR3/NF-κB axis | Cell culture | (248) |
lncRNA ZFAS1 | Up | FLS | miR-296-5p/MMP-15 | Animal study | (249) |
Up | FLS | miR-2682-5p/ADAMTS9 axis | Cell culture | (250) | |
linc00152 | Up | FLS | Wnt/β-catenin pathway | Cell culture | (251) |
lncRNA MALAT1 | Down | PBMC | Notch pathway | Cell culture | (252) |
lncRNA GAS5 | Down | FLS | miR-128-3p/HDAC4 axis | Cell culture | (253) |
Down | ST, FS | HIPK2 signaling | Cell culture | (254) | |
lncRNA HAND2-AS1 | Down | MSC-exos | miR-143-3p/TNFAIP3/NF-κB pathway | Cell culture | (255) |
lncRNAS56464.1 | Up | FLS | miR−152−3p/Wnt pathway | Cell culture | (256) |
lncRNA PICSAR | Up | FLS | miRNA-4701-5p signaling | Cell culture | (257) |
lncRNA MEG3 | Down | FLS | miR-141/AKT/mTOR pathway | Animal study | (258) |
lncRNA ITSN1-2 | Up | FLS | NOD2/RIP2 pathway | Cell culture | (259) |
lncAL928768.3 | Up | FLS | – | – | (260) |
lncAC091493.1 | Up | FLS | – | – | (260) |
lncRNA HOTTIP | Up | FLS | SFRP1 demethylation | Cell culture | (261) |
lncRNA HIX003209 | Up | PBMC | TLR4/NF-κB pathway | Cell culture | (262) |
lncRNA FER1L4 | Down | ST, FLS | NLRC5 signaling | Cell culture | (263) |
lncRNA CASC2 | Down | Plasma | IL−17 signaling | Cell culture | (264) |
lncRNA PlncRNA-1 | Down | Serum, SF | TGF-β1 signaling | Cell culture | (265) |
lncRNA H19 | Up | FLS | Notch pathway | Cell culture | (266) |
Up | FLS | miR-124a | Animal study | (267) | |
lncRNA RP11-83J16.1 | Down | FLS | β-catenin pathway | Cell culture | (268) |
lncRNA H19 | Down | FLS | NF-κB and JNK/p38 MAPK pathways | Cell culture | (269) |
lncRNA XIST | Up | CT | STAT3 signaling | Animal study | (270) |
lncRNA SNHG1 | Up | FLS | PTBP1 signaling | Cell culture | (271) |
lncRNA THRIL | Up | Serum | PI3K/AKT pathway | Cell culture | (272) |
circRNAs | |||||
circ_0088036 | Up | FLS | miR-140-3p/SIRT 1 axis | Cell culture | (273) |
circ_0000396 | Down | FLS | miR-203/HBP1 axis | Cell culture | (274) |
circ_AFF2 | Up | FLS | miR-375/TAB2 axis | Cell culture | (275) |
circ_0130438 | Down | PBMC | – | – | (276) |
circ_0002715 | Up | PB | – | – | (277) |
circ_0035197 | Up | PB | – | – | (277) |
circRNA_09505 | Up | PBMC | miR-6089/AKT1/NF-κB axis | Animal study | (278) |
circFADS2 | Down | AC | miR-498/mTOR pathway | Cell culture | (279) |
circ_0000175 | Down | PBMC | – | – | (280) |
Circ_0008410 | Up | PBMC | – | – | (280) |
FLS, fibroblast-like synoviocytes; CT, cartilage tissues; AC, articular chondrocytes; ST, synovial tissues; BM-MSC-Evs, bone marrow mesenchymal stem cell -derived extracellular vesicles; MSC-exos, mesenchymal stem cell-derived exosomes; PB, peripheral blood; FoxC1, forkhead box C1; PTGS2, prostaglandin-endoperoxide synthase 2; SOX5, sex determining region Y-box protein 5; CTGF, connective tissue growth factor; SFDE, synovial fibroblast-derived exosomes; PDK4, pyruvate dehydrogenase kinase 4; NF-ΚB, nuclear factor kappa-B; RANKL, receptor activator of nuclear factor-kb ligand; MDM2, murine double minute-2; SIRT6, sirtuin 6; TLR3, toll-like receptor 3; BMP, bone morphogenetic protein; Smad, mouse signal transduction molecule; MMP-15, matrix metalloproteinase 15; XBP1, X-box binding protein 1; Wnt, wingless and integration-1; ADAM, a disintegrin and metalloprotease 10; SCUBE2, signal peptide-CUB-EGF-like containing protein 2; MAPK, mitogen-activated protein kinase; ERK, extracellular regulated protein kinase; HBP1, HMG-box transcription factor 1; HDAC4, histone deacetylase 4; TNFAIP3, tumor necrosis factor alpha-inducible protein 3; TAB2, TAK1-binding 2; ATM, ataxia‐telangiectasia mutated; ATR, ATM-Rad3-related; JAK, janus kinase; STAT, signal transducers and activators of transcription; TLR 5, toll-like receptor 5; DDK1, dickkopf 1; PI3K, phosphatidylinositol 3-kinase; REST, presentational state transfer; PBM, peripheral blood monocytes; FOXO3a, forkhead box O3 alpha; SIRT6, sirtuin 6; HMGB1, high-mobility group box protein 1; C/EBPβ, CCAAT enhancer-binding proteinβ; IGF-1R, insulin-like growth factor 1 receptor; HIPK2, homeodomain-interacting protein kinase 2; SOCS 3, suppressors of cytokine signaling 3; NOD2, nucleotide-binding oligomerization domain 2; RIPK2, receptor interacting serine threonine kinase 2; NLRC5, nucleotide oligomerisation domain-like receptors 5; TGF-b1, transforming growth factor beta 1; PTBP1, polypyridine tract-binding protein 1; HIPK2, homeodomain-interacting protein kinase 2; THBS2, thrombospondin 2; PBMC, peripheral blood monouclear cell; exos: exosomes; ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9; mTOR, mammalian target of rapamycinMammalian target of rapamycin.