TABLE 6.

MIC values for doxycycline obtained by MAPt of blood cultures and whole blood samples inoculated with Y. pestis derivatives with reduced susceptibility to doxycycline.

Sample (cfu/ml)	MIC (μg/ml) by MAPt*
	Doxycycline
Blood cultures
1.8 × 103	16
2.2 × 103	16
104	16
2.2 × 104	16
1.3 × 105	16
2.5 × 105	16
1.5 × 106	16
1.9 × 106	16
Whole blood
103	8
1.7 × 103	8
8 × 103	8
1.2 × 104	8
9.3 × 104	8
1.3 × 105	8
8.6 × 105	8
1.2 × 106	8
MIC by standard AST**
5 × 105	16–32

Duration of the test: *MAPt: 13 h. **Standard test: 2–3 days.