TABLE 7.
MIC values for doxycycline obtained by MAPt of blood cultures and whole blood samples inoculated with Y. pestis derivatives with reduced susceptibility to ciprofloxacin.
| Sample (cfu/ml) | MIC (μg/ml) by MAPt* |
| Ciprofloxacin | |
| Blood cultures | |
| 1.4 × 103 | 4 |
| 1.9 × 103 | 4 |
| 9.6 × 103 | 4 |
| 1.2 × 104 | 4 |
| 1.2 × 105 | 4 |
| 1.7 × 105 | 4 |
| 1.2 × 106 | 4 |
| 1.9 × 106 | 4 |
| Whole blood | |
| 1.7 × 103 | 4 |
| 2 × 103 | 4 |
| 8.6 × 103 | 4 |
| 1.4 × 104 | 4 |
| 9.3 × 104 | 4 |
| 1.7 × 105 | 4 |
| 9.6 × 105 | 4 |
| 1.9 × 106 | 4 |
| MIC by standard AST** | |
| 5 × 105 | 2–4 |
Duration of the test: *MAPt: 13 h. **Standard test: 2–3 days.