Table 4.
Drug Effect Questionnaire Responses for N2O and Ketamine
| Effect size (95% CI) | |||||
|---|---|---|---|---|---|
| N2O | Ketamine | ||||
| Mean Pre (SD) | Mean Peri (SD) | Mean Post (SD) | (current study) | (Morgan et al., 2004) | |
| Like | |||||
| Medical air | 18.34 (26.03) | 14.72 (18.69) | 6.72 (14.07) | ||
| N2O | 15.34 (24.64) | 50.06 (28.29) | 27.44 (24.70) | 1.46 (0.92, 2.02) | 1.44 (0.73, 2.21) |
| Want more | |||||
| Medical air | - | 4.03 (7.51) | 0.69 (1.86) | ||
| N2O | - | 25.03 (23.34) | 17.44 (17.87) | 1.20 (0.67, 1.74) | 1.06 (0.37, 1.78) |
| Feel | |||||
| Medical air | 0.09 (0.30) | 3.47 (4.68) | 1.44 (3.67) | ||
| N2O | 0.00 (0.00) | 63.38 (23.21) | 20.84 (12.38) | 3.53 (2.78, 4.37) | 2.23 (1.42, 3.11) |
| High | |||||
| Medical air | 0.09 (0.30) | 1.16 (2.24) | 1.13 (2.66) | ||
| N2O | 0.00 (0.00) | 53.31 (27.51) | 14.16 (14.03) | 2.65 (2.00, 3.36) | NR |
| Dislike | |||||
| Medical air | 0.97 (2.61) | 5.53 (9.83) | 0.84 (2.53) | ||
| N2O | 0.06 (0.25) | 18.53 (15.90) | 12.31 (16.95) | 0.97 (0.46, 1.50) | NR |
Abbreviations: Med, medical; NR, outcome not reported.
Pre, peri and post subjective ratings for “liking,” “wanting more,” “feeling [the effect],” “[feeling] high,” “disliking,” for medical air and N2O. Effect sizes are Hedges’ g based on peri-inhalation (trimmed) means (SDs) for medical air and N2O. For comparison, the right-hand column displays effect sizes for the same outcomes (where available) for ketamine (0.4 mg/kg) versus medical air, obtained 10 minutes after infusion began based on data extracted from graphs presented in Morgan et al (2004).