Figure 2.

The effects of a single (A) and repeated (B) administration of ketamine (10 mg/kg/day) on LC neurons firing and burst activity 1 and 3 days after the last injection. Experiments are carried out until significant effects on firing and burst activity disappear. Each dot indicates a value for an individual data point. Histograms show data as mean values ± SEM. Medians are indicated in dashed lines when Mann-Whitney test was used. Statistical significance is indicated where it applies. *P < .05 when compared to control.