Table 2.
Effect of acute (A) and repeated (B) administration of ketamine on discharge parameters of LC NE neurons 1 and 3 days after last injection.
| Firing activity (Hz) | Burst activity (% neurons firing in burst) | |||||
|---|---|---|---|---|---|---|
| Mean | Median | Mean | Median | Rats, n | Neurons, n | |
| A. Single regimen | ||||||
| Control (day 1) | 1.57 ± 0.09 | 1.33 | 38.20 ± 6.41 | __ | 5 | 84 |
| Ketamine (day 1) | 1.60 ± 0.08 | 1.62a | 28.40 ± 6.04b | __ | 5 | 83 |
| B. Repeated regimen | ||||||
| Control (day 1) | 1.58 ± 0.08 | 1.47 | 33.60 ± 6.87 | __ | 5 | 90 |
| Control (day 3) | 1.64 ± 0.08 | 1.60 | 35.17 ± 6.12 | __ | 6 | 67 |
| Ketamine (day 3) | 1.54 ± 0.08 | 1.40d | 37.80 ± 4.96f | __ | 5 | 67 |
Results are expressed as mean ± S.E.M. Median values were also shown when Mann-Whitney test was used. (A) Firing activity: aMann-Whitney test, U = 3271, P =.5. Burst activity: bTwo-tailed t test, t(8) = 1.1, P =.3. (B) Firing activity: cMann-Whitney test, U = 1471, P <.001; dMann-Whitney test, U = 2036, P =.4. Burst activity: eTwo-tailed t test, t(8) = -1.9, P =.1; fTwo-tailed t test, t(9) = -0.3, P =.8. * indicate significant statistical difference with P <.05.