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. 2020 Oct 14;2(14):2151–2155. doi: 10.1016/j.jaccas.2020.07.053

Figure 2.

Figure 2

Histological and Immunohistochemical View of the Mitral Valve Resectate

(A) Pronounced destruction of the valve stroma by inflammatory cell infiltrates and geographic, granulocyte-rich necrosis (see enlargement); hematoxylin-eosin staining. (B) Poorly delineated granulomas with central neutrophilic microabscesses, neutrophilic granulocytes marked in red; ASD-CL (naphthol AS-D chloroacetate) staining. (C) Immunohistochemical staining of granuloma with CD68-positive macrophages (brown). (D) Inflammatory destruction of the elastic valve stroma (elastic fibers in black); Elastica van Gieson staining.