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. 2021 Jul 21;27:10760296211034579. doi: 10.1177/10760296211034579

Table 1.

Baseline Characteristics of ACS Patients Undergoing PCI.

Variable SII < 628.60 (n = 812) SII ≥ 628.60 (n = 741) P dNLR < 2.29 (n = 846) dNLR ≥ 2.29
(n = 707)
P
Demographics and clinical data, n (%)
 Male 608 (74.88) 555 (74.90) 0.992 623 (73.64) 540 (76.38) 0.215
 Age ≥ 65 years 186 (22.91) 183 (24.70) 0.408 190 (22.46) 179 (25.32) 0.187
 Smoking 424 (52.22) 383 (51.82) 0.876 425 (50.24) 383 (54.17) 0.122
 Dyslipidemia 153 (18.84) 186 (25.10) 0.003 167 (19.74) 172 (24.33) 0.029
 Hypertension 463 (57.02) 451 (60.86) 0.124 497 (58.75) 417 (58.98) 0.925
 Diabetes mellitus 210 (25.86) 183 (24.70) 0.598 222 (26.24) 171 (24.19) 0.354
 History of stroke 114 (14.04) 107 (14.44) 0.821 121 (14.30) 100 (14.14) 0.929
 History of TIA 2 (0.25) 3 (0.40) 0.582 4 (0.47) 1 (0.14) 0.251
 HF 65 (8.00) 91 (12.28) 0.005 64 (7.57) 92 (13.01) <0.001
 CGS 9 (1.11) 15 (2.02) 0.144 13 (1.54) 11 (1.56) 0.976
 Family history of CAD 130 (16.00) 89 (12.01) 0.024 127 (15.01) 92 (13.01) 0.260
 UA 442 (54.43) 173 (23.35) <0.001 466 (55.08) 149 (21.07) <0.001
 STEMI 252 (31.03) 440 (59.38) <0.001 260 (30.73) 432 (61.10) <0.001
 NSTEMI 118 (14.53) 128 (17.27) 0.139 120 (14.18) 126 (17.82) 0.051
Laboratory data, M(Q1, Q3)
 WBC count (109/L) 6.97 (5.73, 8.70) 9.39 (7.52, 11.40) <0.001 7.00 (5.79, 8.89) 9.44 (7.58, 11.46) <0.001
 Platelet count (109/L) 203.00 (172.00, 240.00) 223.50 (191.75, 265.25) <0.001 216.00 (180.00, 255.00) 213.00 (178.00, 247.00) 0.351
 Neutrophil count (109/L) 3.87 (3.11, 4.84) 7.53 (5.67, 9.50) <0.001 3.93 (3.11, 4.88) 7.66 (5.87, 9.59) <0.001
 Lymphocyte count (109/L) 2.10 (1.60, 2.62) 1.30 (0.89, 1.70) <0.001 2.10 (1.60, 2.61) 1.26 (0.88, 1.65) <0.001
 Monocyte count (109/L) 0.44 (0.34, 0.57) 0.42 (0.29, 0.60) 0.107 0.45 (0.35, 0.5) 0.39 (0.28, 0.57) <0.001
 NLR 1.88 (1.41, 2.44) 5.34 (3.63, 9.06) <0.001 1.91 (1.43, 2.47) 5.72 (3.91, 9.38) <0.001
 PLR 97.76 (74.94, 121.77) 172.44 (132.81, 237.42) <0.001 104.23 (79.12, 133.62) 167.18 (121.93, 237.08) <0.001
 MPV (fL) 10.40 (9.90, 11.00) 10.30 (9.70, 11.00) 0.144 10.40 (9.80, 10.93) 10.40 (9.80, 11.00) 0.268
 PDW (%) 12.10 (11.00, 13.40) 12.00 (10.90, 13.40) 0.222 12.00 (10.90, 13.30) 12.10 (11.000, 13.40) 0.211
 ALB (g/L) 41.60 (38.90, 43.80) 41.08 (38.48, 43.46) 0.061 41.59 (38.90, 43.80) 41.00 (38.40, 43.40) 0.020
 CK-MB (U/L) 13.79 (9.00, 23.00) 26.00 (12.50, 101.50) <0.001 13.77 (9.00, 22.00) 27.33 (13.00, 114.00) <0.001
 Cr (μmol/L) 67.41 (58.47, 78.30) 67.00 (58.99, 78.31) 0.441 67.71 (58.43, 78.22) 66.77 (58.95, 78.66) 0.673
 Serum uric acid (μmol/L) 326.40 (265.70, 384.60) 328.95 (263.73, 385.6) 0.767 325.38 (261.65, 385.50) 330.40 (268.46, 384.00) 0.368
Echocardiography, n (%)
 LAa 167 (23.29) 190 (27.78) 0.054 182 (24.17) 175 (27.01) 0.224
 LVEDDa 164 (22.81) 188 (27.45) 0.045 173 (22.88) 179 (27.62) 0.041
 LVEF < 40% 17 (2.36) 24 (3.50) 0.205 17 (2.25) 24 (3.70) 0.106
Coronary angiogram, n (%)
 1 vessel 263 (32.39) 224 (30.23) 0.360 268 (31.68) 219 (30.98) 0.766
 2 vessels 249 (30.67) 245 (33.06) 0.311 272 (32.15) 222 (31.40) 0.752
 3 vessels 300 (36.95) 272 (36.71) 0.922 306 (36.17) 266 (37.62) 0.554
Drugs, n (%)
 Aspirin 801 (98.65) 730 (98.52) 0.829 833 (98.46) 698 (98.73) 0.661
 Clopidogrel 652 (80.30) 572 (77.19) 0.135 680 (80.38) 544 (76.94) 0.099
 Ticagrelor 147 (18.10) 158 (21.32) 0.111 152 (17.97) 153 (21.64) 0.070
 β-blockers 422 (51.97) 375 (50.61) 0.591 443 (52.36) 354 (50.07) 0.368
 ACEI/ARB 352 (43.35) 346 (46.69) 0.186 363 (42.91) 335 (47.38) 0.077
 Statins 796 (98.03) 730 (98.52) 0.464 829 (97.99) 697 (98.59) 0.372
 Diuretic 48 (5.91) 62 (8.37) 0.060 51 (6.03) 59 (8.35) 0.076

Abbreviations: ACS, acute coronary syndrome; PCI, percutaneous coronary intervention; SII, systemic immune-inflammation index; dNLR, derived neutrophil-to-lymphocyte ratio; TIA, transient ischemic attack; HF, heart failure; CGS, cardiogenic shock; CAD, coronary artery disease; UA, unstable angina; STEMI, ST-segment elevation myocardial infarction; NSTEMI, non-ST-segment elevation myocardial infarction; WBC, white blood cell; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; MPV, mean platelet volume; PDW, platelet distribution width; ALB, albumin; CK-MB, creatine phosphokinase isoenzyme; Cr, creatinine; LA, left atrium; LVEDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; ACEI/ARB, angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker.

a above the upper limit of normal values.