Table 1.
Variable | SII < 628.60 (n = 812) | SII ≥ 628.60 (n = 741) | P | dNLR < 2.29 (n = 846) | dNLR ≥ 2.29 (n = 707) |
P |
---|---|---|---|---|---|---|
Demographics and clinical data, n (%) | ||||||
Male | 608 (74.88) | 555 (74.90) | 0.992 | 623 (73.64) | 540 (76.38) | 0.215 |
Age ≥ 65 years | 186 (22.91) | 183 (24.70) | 0.408 | 190 (22.46) | 179 (25.32) | 0.187 |
Smoking | 424 (52.22) | 383 (51.82) | 0.876 | 425 (50.24) | 383 (54.17) | 0.122 |
Dyslipidemia | 153 (18.84) | 186 (25.10) | 0.003 | 167 (19.74) | 172 (24.33) | 0.029 |
Hypertension | 463 (57.02) | 451 (60.86) | 0.124 | 497 (58.75) | 417 (58.98) | 0.925 |
Diabetes mellitus | 210 (25.86) | 183 (24.70) | 0.598 | 222 (26.24) | 171 (24.19) | 0.354 |
History of stroke | 114 (14.04) | 107 (14.44) | 0.821 | 121 (14.30) | 100 (14.14) | 0.929 |
History of TIA | 2 (0.25) | 3 (0.40) | 0.582 | 4 (0.47) | 1 (0.14) | 0.251 |
HF | 65 (8.00) | 91 (12.28) | 0.005 | 64 (7.57) | 92 (13.01) | <0.001 |
CGS | 9 (1.11) | 15 (2.02) | 0.144 | 13 (1.54) | 11 (1.56) | 0.976 |
Family history of CAD | 130 (16.00) | 89 (12.01) | 0.024 | 127 (15.01) | 92 (13.01) | 0.260 |
UA | 442 (54.43) | 173 (23.35) | <0.001 | 466 (55.08) | 149 (21.07) | <0.001 |
STEMI | 252 (31.03) | 440 (59.38) | <0.001 | 260 (30.73) | 432 (61.10) | <0.001 |
NSTEMI | 118 (14.53) | 128 (17.27) | 0.139 | 120 (14.18) | 126 (17.82) | 0.051 |
Laboratory data, M(Q1, Q3) | ||||||
WBC count (109/L) | 6.97 (5.73, 8.70) | 9.39 (7.52, 11.40) | <0.001 | 7.00 (5.79, 8.89) | 9.44 (7.58, 11.46) | <0.001 |
Platelet count (109/L) | 203.00 (172.00, 240.00) | 223.50 (191.75, 265.25) | <0.001 | 216.00 (180.00, 255.00) | 213.00 (178.00, 247.00) | 0.351 |
Neutrophil count (109/L) | 3.87 (3.11, 4.84) | 7.53 (5.67, 9.50) | <0.001 | 3.93 (3.11, 4.88) | 7.66 (5.87, 9.59) | <0.001 |
Lymphocyte count (109/L) | 2.10 (1.60, 2.62) | 1.30 (0.89, 1.70) | <0.001 | 2.10 (1.60, 2.61) | 1.26 (0.88, 1.65) | <0.001 |
Monocyte count (109/L) | 0.44 (0.34, 0.57) | 0.42 (0.29, 0.60) | 0.107 | 0.45 (0.35, 0.5) | 0.39 (0.28, 0.57) | <0.001 |
NLR | 1.88 (1.41, 2.44) | 5.34 (3.63, 9.06) | <0.001 | 1.91 (1.43, 2.47) | 5.72 (3.91, 9.38) | <0.001 |
PLR | 97.76 (74.94, 121.77) | 172.44 (132.81, 237.42) | <0.001 | 104.23 (79.12, 133.62) | 167.18 (121.93, 237.08) | <0.001 |
MPV (fL) | 10.40 (9.90, 11.00) | 10.30 (9.70, 11.00) | 0.144 | 10.40 (9.80, 10.93) | 10.40 (9.80, 11.00) | 0.268 |
PDW (%) | 12.10 (11.00, 13.40) | 12.00 (10.90, 13.40) | 0.222 | 12.00 (10.90, 13.30) | 12.10 (11.000, 13.40) | 0.211 |
ALB (g/L) | 41.60 (38.90, 43.80) | 41.08 (38.48, 43.46) | 0.061 | 41.59 (38.90, 43.80) | 41.00 (38.40, 43.40) | 0.020 |
CK-MB (U/L) | 13.79 (9.00, 23.00) | 26.00 (12.50, 101.50) | <0.001 | 13.77 (9.00, 22.00) | 27.33 (13.00, 114.00) | <0.001 |
Cr (μmol/L) | 67.41 (58.47, 78.30) | 67.00 (58.99, 78.31) | 0.441 | 67.71 (58.43, 78.22) | 66.77 (58.95, 78.66) | 0.673 |
Serum uric acid (μmol/L) | 326.40 (265.70, 384.60) | 328.95 (263.73, 385.6) | 0.767 | 325.38 (261.65, 385.50) | 330.40 (268.46, 384.00) | 0.368 |
Echocardiography, n (%) | ||||||
LAa | 167 (23.29) | 190 (27.78) | 0.054 | 182 (24.17) | 175 (27.01) | 0.224 |
LVEDDa | 164 (22.81) | 188 (27.45) | 0.045 | 173 (22.88) | 179 (27.62) | 0.041 |
LVEF < 40% | 17 (2.36) | 24 (3.50) | 0.205 | 17 (2.25) | 24 (3.70) | 0.106 |
Coronary angiogram, n (%) | ||||||
1 vessel | 263 (32.39) | 224 (30.23) | 0.360 | 268 (31.68) | 219 (30.98) | 0.766 |
2 vessels | 249 (30.67) | 245 (33.06) | 0.311 | 272 (32.15) | 222 (31.40) | 0.752 |
3 vessels | 300 (36.95) | 272 (36.71) | 0.922 | 306 (36.17) | 266 (37.62) | 0.554 |
Drugs, n (%) | ||||||
Aspirin | 801 (98.65) | 730 (98.52) | 0.829 | 833 (98.46) | 698 (98.73) | 0.661 |
Clopidogrel | 652 (80.30) | 572 (77.19) | 0.135 | 680 (80.38) | 544 (76.94) | 0.099 |
Ticagrelor | 147 (18.10) | 158 (21.32) | 0.111 | 152 (17.97) | 153 (21.64) | 0.070 |
β-blockers | 422 (51.97) | 375 (50.61) | 0.591 | 443 (52.36) | 354 (50.07) | 0.368 |
ACEI/ARB | 352 (43.35) | 346 (46.69) | 0.186 | 363 (42.91) | 335 (47.38) | 0.077 |
Statins | 796 (98.03) | 730 (98.52) | 0.464 | 829 (97.99) | 697 (98.59) | 0.372 |
Diuretic | 48 (5.91) | 62 (8.37) | 0.060 | 51 (6.03) | 59 (8.35) | 0.076 |
Abbreviations: ACS, acute coronary syndrome; PCI, percutaneous coronary intervention; SII, systemic immune-inflammation index; dNLR, derived neutrophil-to-lymphocyte ratio; TIA, transient ischemic attack; HF, heart failure; CGS, cardiogenic shock; CAD, coronary artery disease; UA, unstable angina; STEMI, ST-segment elevation myocardial infarction; NSTEMI, non-ST-segment elevation myocardial infarction; WBC, white blood cell; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; MPV, mean platelet volume; PDW, platelet distribution width; ALB, albumin; CK-MB, creatine phosphokinase isoenzyme; Cr, creatinine; LA, left atrium; LVEDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; ACEI/ARB, angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker.
a above the upper limit of normal values.