Table 1.

Preclinical studies of c-kit+ CPCs performed outside of Dr. Anversa’s laboratory.

No.	Author and year	Species	Model	Route of injection	Outcome	Notes
1	Fischer et al. 2009	Mouse	Acute MI	Intramyocardial	↑function, ↓infarct size
2	Tang et al. 2009	Mouse	Acute MI	Intravenous	↑function, ↓infarct size
3	Tang et al. 2010	Rat	Chronic HF (old MI)	Intracoronary	↑function and structure
4	Li et al. 2011	Mouse	Subacute MI	Intracoronary	↑function and viable tissue
5	Carr et al. 2011	Rat	Acute MI	Intramyocardial	↑function
6	Oskouei et al. 2012	Mouse	Acute MI	Intramyocardial	↑function, ↓scar
7	Mohsin et al. 2012	Mouse	Acute MI	Intramyocardial	↑function, ↓infarct size
8	Wang et al. 2012	Mouse	Acute MI	Intramyocardial	↑structure and function
9	Li et al. 2012	Mouse	Acute MI	Intramyocardial	↑ function
10	Simpson et al. 2012	Rat	Acute MI	Intramyocardial	↑function, ↓infarct size
11	Bolli et al. 2013	Swine	Chronic HF (old MI)	Intramyocardial	↑function, ↓scar
12	Duran et al. 2013	Mouse	Acute MI	Intramyocardial	↑function,* ↓infarct size
13	Alshammary et al. 2013	Rat	Acute MI	Cell sheet transplantation	↑function, ↓fibrosis
14	Ellison et al. 2013	Rat	Acute MI and ISO-induced chronic HF	Intravenous	↑function
15	Williams et al. 2013	Swine	Chronic HF (old MI)	Intramyocardial	↑function, ↓scar
16	Zhang et al. 2014	Mouse	Acute MI	Intramyocardial	↑function, ↓infarct size
17	Hong et al. 2014	Mouse	Subacute MI	Intracoronary	↑function
18	Matsuda et al. 2014	Rat	Acute MI	Intramyocardial	↑function, ↓fibrosis
19	Zakharova et al. 2014	Rat	Chronic HF (old MI)	Retrograde (coronary vein)	↑function, ↓scar
20	Kamata et al. 2014	Swine	Chronic HF (old MI)	Cell sheet transplantation	↑function, ↓fibrosis
21	Zhao et al. 2015	Mouse	Acute MI	Intramyocardial	↑function, ↓infarct size
22	Cai et al. 2015	Mouse	Acute MI	Intramyocardial	↑function, ↓scar
23	Avolio et al. 2015	Mouse	Acute MI	Intramyocardial	↑function, ↓fibrosis
24	J.M. Tang et al. 2015	Rat	Acute MI	Intramyocardial	↑function, ↓infarct size
25	Vahdat et al. 2015	Rat	Acute MI	Intramyocardial	↓infarct size and fibrosis
26	Sharma et al. 2015	Rat	Acute MI	Intramyocardial	↑function, ↓infarct size
27	Zakharova et al. 2015	Rat	Chronic HF (old MI)	Retrograde (coronary vein)	↑function, ↓scar
28	X.L. Tang et al. 2015	Rat	Acute MI	Intracoronary	↑function and structure
29	Karantalis et al. 2015	Swine	Chronic HF (old MI)	Intramyocardial	↑function, ↓scar
30	Taghavi et al. 2015	Feline	ISO-induced chronic HF	Intracoronary	↑function, ↓fibrosis	Not a model of ischemic heart disease
31	Kazakov et al. 2015	Mouse	TAC model	Intravenous	↓LV fibrosis	Not model of ischemic heart disease
32	Wysoczynski et al. 2016	Mouse	Subacute MI	Echo-guided intraventricular	↑function and viable tissue
33	Song et al. 2016	Rat	Acute MI	Unclear	↑function, ↓infarct size
34	Tang et al. 2016	Rat	Acute MI	Intracoronary	↑function and structure
35	Tokita et al. 2016	Rat	Chronic HF (old MI)	Echo-guided intraventricular	↑function and structure
36	Zhang et al. 2016	Rat	Subacute MI	Intramyocardial	↑function, ↓fibrosis
37	Kulandavelu et al. 2016	Swine	Chronic HF (old MI)	Intramyocardial	↑function, ↓scar
38	Li et al. 2017	Rat	Acute MI	Intramyocardial	↑function
39	Vicinanza et al. 2017	Rat	Acute MI	Intramyocardial	↑function
40	Bao et al. 2017	Rat	Chronic HF (old MI)	Intramyocardial	↑function
41	Wehman et al. 2017	Swine	Acute RV injury by PA binding	RV intramyocardial	↑RV function, ↓fibrosis	Not a model of ischemic heart disease
42	Natsumeda et al. 2017	Swine	Chronic HF (old MI)	Intramyocardial	↑function, ↓scar
43	Ma et al. 2018b	Mouse	Acute MI	Intramyocardial	↑function
44	Puddighinu et al. 2018	Mouse	Acute MI	Intramyocardial	↑function
45	Ma et al. 2018a	Mouse	Acute MI	Intramyocardial	↑function
46	Li et al. 2018	Mouse	Acute MI	Intramyocardial	↑function, ↓fibrosis
47	Dergilev et al. 2018	Rat	Acute MI	Cell sheet transplantation	↓infarct size and remodeling
48	Bhutani et al. 2018	Rat	Acute MI	Intramyocardial	↑function, ↓remodeling
49	Tang et al. 2018	Rat	Chronic HF (old MI)	Echo-guided intraventricular	↑function and structure
50	Maxwell et al. 2019	Rat	RV injury by PA banding model	Echo-guided RV intramyocardial	↑RV functional parameters	Not a model of ischemic heart disease

Note: MI, myocardial infarction; HF, heart failure; ISO, isoproterenol; PA, pulmonary artery; RV, right ventricle; TAC, transverse aortic constriction.

^*CPCs were found to be less effective than cortical bone stem cells, but nevertheless, CPCs produced beneficial effects on LV function.