Table 3.
Total invasive cancer |
• No significant interaction by sex |
• No significant interaction by race/ethnicity (signal for greater benefit in African Americans) |
• Significant interaction by body mass index (reduction in those with healthy weights but not in those with elevated body mass index) |
Major cardiovascular disease events a |
• No significant interaction by sex |
• No significant interaction by race/ethnicity |
All-cause mortality |
• No significant interaction by sex |
• No significant interaction by race/ethnicity |
Other endpoints |
• Colorectal adenoma |
° No significant interaction by sex or race/ethnicity |
• Advanced colorectal adenoma |
° Significant interaction by baseline 25(OH)D level (greater benefit in those with levels below 30 ng/mL) |
• Bone mineral density |
° No significant interaction by sex or race/ethnicity |
° Significant interaction by baseline free 25(OH)D level: (greater benefit in those with levels below the median) |
• Chronic knee pain |
° No significant interaction by sex or race/ethnicity |
• Falls |
° No significant interaction by sex or race/ethnicity |
° No significant interaction by body mass index (signal for greater benefit in those with healthy weights but not in those with elevated body mass index) |
• Depression |
° No significant interaction by sex or race/ethnicity |
° No significant interaction by body mass index (signal for greater benefit in those with healthy weights but not in those with elevated body mass index) |
• Chronic kidney disease in individuals with diabetes |
° No significant interaction by race/ethnicity |
A composite of myocardial infarction, stroke, and cardiovascular mortality.