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. 2021 Jul 9;12:695220. doi: 10.3389/fimmu.2021.695220

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Copyright © 2021 Hutchinson, Park, Zanotti, Alvarez-Gonzalez, Zhang, Zhang, Telljohann, Wang, Lakatta, Gearhart and Maul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell subsets in spleen, peritoneal cavity, and aorta from C57BL/6J, ApoE^-/- and ApoE^-/- Aid^-/- mice. (A) Total, (B) germinal center, (C) follicular, and (D) marginal zone B cells were analyzed from spleens of mice at 28 weeks. (E) B1a and (F) B-1b cells were isolated from the peritoneal cavity. (G) Aortic B cells were isolated from the aorta and adjacent fat layer. Symbols represent percentages in individual mice with red line displaying the mean. p-values represent two-tailed T-test.