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. 2021 Jul 9;12:695220. doi: 10.3389/fimmu.2021.695220

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Copyright © 2021 Hutchinson, Park, Zanotti, Alvarez-Gonzalez, Zhang, Zhang, Telljohann, Wang, Lakatta, Gearhart and Maul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum antibody concentrations from mice. (A, B) total immunoglobulin measured by ELISA at 12, 20 and 28 weeks on a high fat diet. (A) IgM and (B) IgG1 from C57BL/6J (black circle), ApoE^-/- (blue triangle) or ApoE^-/- Aid^-/- (green square) mice. Red line represents the mean from 17 or more independent mice. *0.05 > p > 0.01, **0.01 > p > 0.001, ***0.001 > p > 0.0001, ****p < 0.0001. (C–E), IgM and IgG1 antibody titers measured by ELISA at 28 weeks on the diet. (C) MDA-oxLDL, (D) MDA-ApoB100, and (E) ApoB100. IgM sera was diluted 1:1000, and IgG1 sera was diluted 1:200 for analysis. Symbols represent percentages in individual mice with red line displaying the mean from 14-16 mice per genotype. Significance was determined by two-tailed T-test.