. Author manuscript; available in PMC: 2021 Jul 23.

Published in final edited form as: Inorg Chem. 2020 Nov 10;59(23):17473–17487. doi: 10.1021/acs.inorgchem.0c02722

Table 3.

Chronological stability study of [⁸⁹Zr]Zr-complexes with various metals in competition study (PBS, pH 7.4) maintained at 37°C for 7 days and analyzed by Radio-ITLC (n = 3 for each [⁸⁹Zr]Zr-complex with each metal and time point)

Time Point	Complex	% Intact of [⁸⁹Zr]Zr-complexes (n = 3)
Time Point	Complex	Fe³⁺	Zn²⁺	Co²⁺	Cu²⁺	Mg²⁺	Gd³⁺	Ga³⁺
0 h	[⁸⁹Zr]Zr-PCTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-NOTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-TRITA	99.7 ± 0.2	99.6 ± 0.2	99.5 ± 0.2	99.7 ± 0.2	99.6 ± 0.2	99.5 ± 0.2	99.7 ± 0.2
1 d	[⁸⁹Zr]Zr-PCTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-NOTA	99.0 ± 0.1	96.1 ± 0.1	97.7 ± 0.4	96.1 ± 0.2	95.5 ± 0.3	98.3 ± 0.1	97.9 ± 0.1
	[⁸⁹Zr]Zr-TRITA	91.3 ± 0.3	29.2 ± 1.2	35.6 ± 2.3	94.5 ± 0.9	90.4 ± 1.0	88.7 ± 0.8	94.6 ± 0.8
3 d	[⁸⁹Zr]Zr-PCTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-NOTA	98.3 ± 0.2	95.8 ± 0.2	95.7 ± 0.3	92.2 ± 0.3	94.3 ± 0.3	97.2 ± 0.5	95.2 ± 0.6
	[⁸⁹Zr]Zr-TRITA	85.8 ± 0.9	21.1 ± 0.9	18.4 ± 0.5	76.2 ± 1.0	87.9 ± 0.3	67.7 ± 0.9	70.4 ± 0.9
5 d	[⁸⁹Zr]Zr-PCTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-NOTA	97.4 ± 0.3	94.4 ± 0.5	94.8 ± 0.6	90.2 ± 0.3	91.8 ± 0.6	97.0 ± 0.3	93.4 ± 0.1
	[⁸⁹Zr]Zr-TRITA	77.8 ± 1.1	16.5 ± 2.7	15.4 ± 0.8	68.1 ± 1.5	85.5 ± 1.1	59.2 ± 0.7	67.6 ± 0.5
7 d	[⁸⁹Zr]Zr-PCTA	100	100	100	100	100	100	100
	[⁸⁹Zr]Zr-NOTA	96.2 ± 0.2	90.4 ± 0.4	92.9 ± 0.7	87.8 ± 0.9	90.6 ± 0.4	96.3 ± 0.4	89.5 ± 1.5
	[⁸⁹Zr]Zr-TRITA	70.4 ± 0.8	9.4 ± 0.7	7.3 ± 0.6	59.7 ± 0.5	83.9 ± 0.5	57.2 ± 0.6	61.8 ± 1.2