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. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: Inorg Chem. 2020 Nov 10;59(23):17473–17487. doi: 10.1021/acs.inorgchem.0c02722

Table 4.

Chronological in vitro serum stability study of [89Zr]Zr-complexes in human serum maintained at 37°C for 7 days as determined by size exclusion chromatography (n = 3 for each [89Zr]Zr-complex at each time point)

Time point % Intact of [89Zr]Zr-complexes (n = 3)
[89Zr]Zr-PCTA [89Zr]Zr-NOTA [89Zr]Zr-TRITA
0 h 100 100 100
1 d 99.9 ± 0.1 97.7 ± 0.2 80.8 ± 1.1
3 d 99.8 ± 0.1 95.5 ± 0.4 59.1 ± 1.5
5 d 99.6 ± 0.2 91.8 ± 0.3 45.2 ± 2.4
7 d 99.4 ± 0.2 89.2 ± 0.5 32.4 ± 0.6