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Summary of documented molecular interactions in the regulation of sCD146 production by human retinal microvascular endothelial cells (HRMECs) and its effect on retinal Müller glial cells in switching on angiogenic signals. TNF-α = tumor necrosis factor-alpha; VEGF = vascular endothelial growth factor; MMP-9 = matrix metalloproteinase-9; ERK = extracellular-signal regulated kinase; NF-κB = nuclear factor-kappa B.
