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. 2021 Jul 22;62(9):32. doi: 10.1167/iovs.62.9.32

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Copyright 2021 The Authors

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Figure 5. — CD146 protein expression in the retinas of diabetic rats. (A) CD146 protein expression was determined by Western blot analysis on lysates of diabetic (D) and nondiabetic control retinas (C) at 4 weeks (4W) and 12 weeks (12W) after diabetes induction. After determination of the intensity of the CD146 protein band, intensities were adjusted to those of β-actin in the sample. Results are expressed as mean ±SD. One-way ANOVA and independent t-tests were used for comparisons between the three and two groups, respectively. *p < 0.05 compared with the values obtained from nondiabetic controls. #p < 0.05 compared with 4 week diabetic rats. (B) Immunofluorescence detection of CD146 (light green) in 8-week diabetic rat retina. CD146 immunoreactivity is detected in endothelial cells of the capillaries (white arrows). Nuclei were counterstained with DAPI (blue). GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer.