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. 2021 Jul 22;62(9):32. doi: 10.1167/iovs.62.9.32

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Figure 9. — sCD146 induces blood-retinal barrier (BRB) breakdown (panel A). sCD146 was injected intravitreally at the dose of 5 ng/5 µl in one eye and the same volume of phosphate-buffered saline (PBS) was injected in the contralateral eye of normal rats. The BRB was quantified with the fluorescein isothiocyanate-conjugated dextran technique. Results are expressed as mean ± SD of 13 rats. *p < 0.05 compared to the values obtained from PBS-injected eyes (independent t-test). Western blot analysis of rat retinas revealed that intravitreal administration of sCD146 (5 ng/5 µL) induced significant upregulation of the expression of phospho-ERK1/2 (panel B), intercellular adhesion molecule-1 (ICAM-1) (panel C) and vascular endothelial growth factor (VEGF) (panel D) compared to intravitreal administration of PBS. Results are expressed as mean ±SD from three different experiments (*p < 0.05; independent t-test).